Clinical and genetic analysis of a patient with Hb Ottawa in conjunction with β-thalassemia / 中华医学遗传学杂志

Objective@#To analyze the hematological characteristics of a patient with Hb Ottawa in conjunction with β-thalassemia.@*Methods@#Peripheral blood samples from the proband and her parents were collected and subjected to red blood cell analysis and hemoglobin electrophoresis. Genotypes of α- and β-globin genes were also analyzed.@*Results@#The proband and her mother were both heterozygotes for Hb Ottawa and β-thalassemia variant IVS II-654, and presented with typical β-thalassemia trait featuring hypochromic microcytic anemia. An abnormal hemoglobin band was detected upon electrophoresis.@*Conclusion@#Co-existence of Hb Ottawa and β-thalassemia may not aggravate the phenotype.

Clinical and genetic analysis of a patient with Hb Ottawa in conjunction with β -thalassemia / 中华医学遗传学杂志

OBJECTIVE@#To analyze the hematological characteristics of a patient with Hb Ottawa in conjunction with β -thalassemia.@*METHODS@#Peripheral blood samples from the proband and her parents were collected and subjected to red blood cell analysis and hemoglobin electrophoresis. Genotypes of α - and β -globin genes were also analyzed.@*RESULTS@#The proband and her mother were both heterozygotes for Hb Ottawa and β -thalassemia variant IVS II-654, and presented with typical β -thalassemia trait featuring hypochromic microcytic anemia. An abnormal hemoglobin band was detected upon electrophoresis.@*CONCLUSION@#Co-existence of Hb Ottawa and β -thalassemia may not aggravate the phenotype.

Analysis of the Application of Antineoplastic Drugs in Patients with Colorectal Cancer in Our Hospital during 2011-2014 / 中国药房

OBJECTIVE:To provide reference for medication and chemotherapy in patients with colorectal cancer. METH-ODS:Through retrospective study,case histories and doctor’s advice of the colorectal cancer patients receiving chemotherapy in our hospital during 2011-2014 were consulted to analyze the chemotherapy,medication and irrational drug use. RESULTS:A total of 593 cases of colorectal cancer patients with chemotherapy frequency of 1 940 times were collected to analyze the choice of che-motherapy regimen mainly from the following aspects:indications of chemotherapy,choice of chemotherapy regimen,chemothera-py process and chemotherapy period. There was 409 cases of irrational drug use according to the analysis of drug dosage,selection of solvents and drug concentration,the unqualified rate was 21.08% . CONCLUSIONS:The medication and chemotherapy in pa-tients with colorectal cancer in our hospital are basically rational,but there are still certain problems and shortcomings. In future clinical applications,the medication and chemotherapy need to be improved.