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Purpose@#The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors. @*Methods@#Twelve ovarian cancer survivors aged 33–61 years participated voluntarily in this study and were divided into control group (CG, n=6) and exercise group (EG, n=6). They underwent removal of ovarian cancer and received regular care for over one year. Resistance exercise was used as the intervention program conducted 4 days a week for 12 weeks. Skeletal muscle mass, muscle strength, and endurance were assessed at baseline and at week 12. Other dependent variables included adaptive immunocytes related to helper T (Th) cells and immunosuppressors (CD4+ and CD8+). @*Results@#After the intervention, skeletal muscle mass showed positive changes in EG com-pared to CG, although not significantly different. Muscle strength and endurance significantly increased in EG, while there was no significant change in CG. Th1, Th2, and Th1/Th2 ratio were significantly different between both groups. CD4+CD25+T cells and CD4+PD-1+T cells of EG were lower than those of CG. CD8+PD-1+T cells and CD8+TIGIT+T of EG were lower than those of CG. These results can be interpreted as the improved sensitivity of CD4+ and CD8+, which helps the secretion of myokines and cytokines, when cytotoxic substances are injected into the human body. @*Conclusions@#This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.
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Purpose@#Multiple sclerosis is an autoimmune disease that affects the central nerve system, resulting in cumulative loss of motor function. Multiple sclerosis is induced through multiple mechanisms and is caused by inflammation and demyelination. This study aims to evaluate the neuroprotective effect of swimming exercise in experimental autoimmune encephalomyelitis (EAE) rats, an animal model of multiple sclerosis. @*Methods@#EAE was induced by an intradermal injection of 50-μg purified myelin oligodendrocyte glycoprotein 33–55 (MOG33-55) dissolved in 200-μL saline at the base of the tail. The rats in the swimming exercise group were made to swim for 30 minutes once pert a day for 26 consecutive days, starting 5 days after induction of EAE. To compare the effect of swimming exercise with interferon-β, a drug for multiple sclerosis, interferon-β was injected intraperitoneally into rats of the EAE-induced and interferon-β-treated group during the exercise period. @*Results@#Injection of MOG33-55 caused weight loss, decreased clinical disability score, and increased level of pro-inflammatory cytokines and inflammatory mediators in the lumbar spinal cord. Loss of motor function and weakness increased demyelination score. Swimming exercise suppressed demyelination and expression of pro-inflammatory cytokines and inflammatory mediators. These changes promoted recovery of EAE symptoms such as body weight loss, motor dysfunction, and weakness. Swimming exercise caused the same level of improvement as interferon-β treatment. @*Conclusions@#The results of this experiment suggest the possibility of swimming exercise in urological diseases that are difficult to treat. Swimming exercises can be considered for relief of symptom in incurable multiple sclerosis.
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PURPOSE: Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recommended for the prevention and the treatment of these age-related frail states. We investigated the effects of treadmill exercise on muscle strength, myostatin mRNA and protein expression, and gastrocnemius myocytes proliferation in aged rats to investigate the possible antiaging effects of aerobic exercise on skeletal muscles such as pelvic floor muscles and urethral rhabdosphincter muscle. METHODS: In this study, 5-month-old male Sprague-Dawley rats were used as the young-age group (n=20) and 24-month-old rats were used as the old-age group (n=20). Each group was randomly divided into two groups (n=10 in each group): the sedentary and the treadmill exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 minutes, once a day, for 6 weeks. For this study, a weight load test, hematoxylin and eosin staining, real-time and reverse transcription polymerase chain reaction for myostatin mRNA, myostatin western blot, and 5-bromo-2'-deoxyuridine immunohistochemistry were performed in the gastrocnemius muscle. RESULTS: The age-induced reduction of muscle mass and strength was associated with a decrease in myocyte proliferation and an increase in myostatin mRNA and protein expression in the gastrocnemius. However, treadmill exercise improved muscle mass and strength through suppression of myostatin mRNA and protein expression, and myocyte proliferation increase in the gastrocnemius against the aging process. CONCLUSIONS: Aerobic exercise is a useful strategy for enhancing muscle function against aging-induced loss of skeletal muscle mass and functions.
Тема - темы
Animals , Child, Preschool , Humans , Infant , Male , Rats , Aging , Blotting, Western , Bromodeoxyuridine , Eosine Yellowish-(YS) , Exercise , Hematoxylin , Immunohistochemistry , Muscle Cells , Muscle Strength , Muscle Weakness , Muscle, Skeletal , Muscles , Myostatin , Pelvic Floor , Polymerase Chain Reaction , Rats, Sprague-Dawley , Reverse Transcription , RNA, Messenger , Urinary IncontinenceРеферат
PURPOSE: An overactive bladder (OAB) may be defined as urgency that is a sudden, compelling, difficult to defer desire to pass urine that is usually accompanied by frequency and nocturia and possibly by incontinence. Obesity and old age are two factors in various causes of OAB. Several epidemiologic studies have identified positive associations among obesity, old age, urinary incontinence, and OAB. However, although exercise has been known to improve obesity and reduce incontinent urine loss, little research has been done in elderly women. Therefore, we investigated the effects of exercise on obesity-related metabolic factors, blood lipid factors, and OAB symptoms in elderly Korean women. METHODS: Twenty-one women aged between 69 and 72 years were recruited from the Seoul senior towers in Korea. All subjects worked out on a motorized treadmill and stationary cycle for 40 minutes, respectively, and performed resistance exercise for 30 minutes once a day for 52 weeks. Body composition, blood pressure, blood lipids, OAB symptom score, and King's health questionnaire were investigated and analyzed. RESULTS: Before performing physical exercise, all subjects showed increased OAB symptoms in association with enhanced body mass index (BMI), percentage fat, and blood lipid profiles. However, physical exercise for 52 weeks suppressed BMI, percentage fat, and blood lipid profiles and thus improved OAB symptoms. CONCLUSIONS: We suggest that long-term physical exercise can be a valuable tool for remarkable improvement of OAB.
Тема - темы
Aged , Female , Humans , Blood Pressure , Body Composition , Body Mass Index , Epidemiologic Studies , Exercise , Korea , Nocturia , Obesity , Urinary Bladder, Overactive , Urinary IncontinenceРеферат
BACKGROUND: Gravity traction is a widely used conservative procedure, and several studies using various techniques have reported changes in blood pressure (BP) or heart rate (HR) or stress variables in the head-down tilting position, with varying results. The purpose of this study was to investigate BP, HR and serum lactic acid (LA) responses to inverted gravity traction at six angles. METHODS: Thirty volunteers (males 15, females 15) were assigned randomly to either of two experimental groups. After the resting BP, HR and LA concentration were measured in the sitting position, they were measured repeatedly at standing, supine, and inverted at -30, -60 and -90 degrees every 2.5 minute. RESULTS: Compared to the systolic BP (SBP) at sitting, SBP decreased at standing and at inverted -30degrees and increased at -60degrees and -90degrees in the males group, whereas SBP decreased at supine to inverted -60degrees and increased at -90degrees in the females group. Compared to the diastolic BP (DBP) at sitting, DBP diastolic blood pressure (DBP) decreased at standing to -60degrees in both groups and increased at inverted -90degrees. Compared to HR at sitting, HR decreased at supine to -90degrees in both groups. The results of the post hoc test comparisons showed that the SBP, DBP, and HR differed significantly at all six positions. However, compared to serum LA at sitting, LA at all positions were not significantly different in both groups. CONCLUSIONS: As seen in previous research, our results showed increases in BP and HR at inverted -90degrees. However, BP and HR at the other inverted positions including supine showed decreases. LA did not change significantly at any of the positions. Finally, our study showed that angles above -30degrees or -60degrees can benefits the cardiovascular system in young people.
Тема - темы
Female , Humans , Male , Blood Pressure , Cardiovascular System , Gravitation , Head-Down Tilt , Heart , Heart Rate , Lactic Acid , Posture , TractionРеферат
BACKGROUND: Although there were many studies about increasing the bone mineral density(BMD) of the elderly by exercise program, the results of weekly exercise participation degree are still to be not prepared. Therefore I examined that the effect of weekly exercise participation degree on BMD level of the elderly. METHODS: Subjects were 93 older adults (male=43, female=50) residing in Seoul-Seniors-To-wei. These people are either participating in exercise program for a year, or not in Song-Do Hospital Exercise Prescription Center. Among the elderly, if one were took part in exercise program 5 days or more weekly, they are classified in Group A(male = 14, female= 14), if one were took part in exercise program 5 days weekly, they are classified in Group B (male = 14, female = 17), if one were took part in exercise program a day weekly. they are classified in Group C(mal =8, female= 13). and if one were not took part in exercise program, they are involved in Group I)(male=7, female=6). All the measured data were represented by mean and standard deviation using SPSS package(ver10.0). The statistical techniques for data analysis of BMD levels of the four groups in male and female groups were to analyze the differences among groups by one way ANOVA. And then I performed the Scheffe post-hoc method forinvestigating exactly the differences among groups. The 5% level of significance was used as the critical level for acceptance of hypotheses for the study. RESULTS: There were no statistical difference (p>0.05) among four male or female groups in BMD levels of head, anus, trunk, ribs, and pelvis parts. But there were statistical differences(p <0.05) among four male or female groups in BMD levels of legs, spine, and total. On the condition of legs, the BMD level of Group A exercised in 5 days or more weekly was 1.58 g/cm2 (F=6.774, p=0.001) in male groups and 1.17 g/cm2 (F =6.616. p=0.001) in female groups. These levels were the highest among four groups. And on the condition of spine, the BMD level of Group A was 1.17 g/cm2(F=7.732, p=0.001) in male groups and 1.16 g/cm2(F=6.243, p=0.002) in female groups. These levels were the highest among four groups. Also on the cutiditiuii of total, the BMD level of Group A was 1.53 g/cm2(F=5.677, p=0.003) in male groups and 1.1 g/cm(F=5.283, p=0.003)in female groups. These levels were the highest among four groups. CONCLUSION: Although the exercise is advantageous to the elderly people, if they are participated in 5 days or more weekly, they will be gained more benefit on BMD level and so on.
Тема - темы
Adult , Aged , Female , Humans , Male , Anal Canal , Bone Density , Head , Leg , Pelvis , Prescriptions , Ribs , Spine , Statistics as TopicРеферат
No abstract available.