Carga de trabalho, cansaço e impotência entre profissionais de enfermagem no enfrentamento da COVID-19 / Workload, fatigue, and helplessness among nursing professionals in dealing with COVID-19 / Carga laboral, fatiga e impotencia entre los profesionales de enfermería durante la COVID-19

Objetivo: investigar a relação entre carga de trabalho e o registro de cansaço e impotência em profissionais de enfermagem na linha de frente contra a COVID-19. Método: estudo misto, na etapa transversal com 91 profissionais de um hospital público do Rio Grande do Sul, 31 dos quais foram entrevistados em profundidade. Utilizaram-se o Self-Reporting Questionnaire, Perceived Stress Scalee Oldenburg Burnout Inventory, analisados estatisticamente. Resultados:indicam correlação positiva moderada entre cansaço e impotência (p<0,01), ambos correlacionados positivamente com carga de trabalho (p<0,05) e negativamente com experiência profissional (p<0,05). Regressões lineares indicaram o tempo de exercício profissional como preditor negativo (p<0,05) para cansaço e impotênciae o número de horas trabalhadas na semana como preditor positivo do cansaço (p<0,05) e adjuvante no modelo final para impotência (p=0,089), com bom ajuste (p=0,013). Conclusões:é necessário ajustar a proteção das equipes em relação ao volume e à extensãodas jornadas de trabalho.

Objective: to investigate the relationship between workload and the reporting of fatigue and helplessness among nursing professionals on the front lines against COVID-19. Method: a mixed-method study, in the cross-sectional stage with 91 professionals from a public hospital in Rio Grande do Sul, 31 of whom were interviewed in depth. The Self-Reporting Questionnaire, Perceived Stress Scale, and Oldenburg Burnout Inventory were used, statistically analyzed. Results: indicate a moderate positive correlation between fatigue and helplessness (p<0.01), both positively correlated with workload (p<0.05) and negatively with professional experience (p<0.05). Linear regressions indicated professional practice time as a negative predictor (p<0.05) for fatigue and helplessness, and the number of hours worked per week as a positive predictor of fatigue (p<0.05) and an adjunct in the final model for helplessness (p=0.089), with a good fit (p=0.013). Conclusions: it is necessary to adjust the protection of teams regarding the volume and duration of working hours.

Objetivo: investigar la relación entre carga de trabajo y registro de cansancio y impotencia en profesionales de enfermería en la línea de frente contra la COVID-19. Método: estudio mixto, en la etapa transversal con 91 profesionales de un hospital público de Rio Grande do Sul, 31 de los cuales fueron entrevistados en profundidad. Se utilizaron escalas analizados estadísticamente. Resultados: indican correlación positiva moderada entre cansancio y impotencia (p<0.01), ambos correlacionados positivamente con carga de trabajo (p<0.05) y negativamente con experiencia profesional (p<0.05). Las regresiones lineales indicaron tiempo de ejercicio profesional como un predictor negativo (p<0.05) para cansancio y impotencia, y número de horas trabajadas por semana como un predictor positivo del cansancio (p<0.05) y un adjunto en el modelo final para la impotencia (p=0.089), con un buen ajuste (p=0.013). Conclusiones: es necesario ajustar la protección de los equipos en relación con el volumen y la duración de las jornadas laborales.

The Effect and Mechanism of Fructus lycii on Improvement of Exercise Fatigue Using a Network Pharmacological Approach with in vitro Experimental Verification / 生物医学与环境科学（英文）

OBJECTIVE@#This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.@*METHODS@#A network pharmacological approach was used to explore potential mechanisms of action of Fructus lycii. Skeletal muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological analysis.@*RESULTS@#Six potential active components, namely quercetin, β-sitosterol, stigmasterol, 7-O-methylluteolin-6-C-beta-glucoside_qt, atropine, and glycitein, were identified to have potency in improving exercise fatigue via multiple pathways, such as the PI3K-Akt, neuroactive ligand-receptor interaction, IL-17, TNF, and MAPK signaling pathways. The immunofluorescence results indicated that quercetin, a significant active component in Fructus lycii, increased the mean staining area of 2-NBDG, TMRM, and MitoTracker, and decreased the area of CellRox compared to the control. Furthermore, the protein expression levels of p-38 MAPK, p-MAPK, p-JNK, p-PI3K, and p-AKT markedly increased after quercetin treatment.@*CONCLUSION@#Fructus lycii might alleviate exercise fatigue through multiple components and pathways. Among these, quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative stress. The PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.

Sobrevivência em fadiga de coroas bioinspiradas bilaminadas: estudo in vitro / Fatigue survival rate of bioinspired bilaminar crowns: in vitro study

O objetivo deste estudo foi avaliar o comportamento biomecânico através da resistência à fadiga e análise por elementos finitos de coroas bioinspiradas bilaminadas com infraestruturas modificadas na superfície vestibular (Estudo A) e utilizando diferentes materiais cerâmicos com módulos elásticos distintos (Estudo B). Para isso, foram confeccionados 90 preparos para coroa total em resina epóxi G10, sobre os quais foram preparadas coroas bioinspiradas de acordo com os seguintes grupos: Estudo A - IC (infraestrutura convencional), IME (infraestrutura modificada estratificada) e IMC (infraestrutura modificada cimentada), todas confeccionadas em dissilicato de lítio (infraestrutura) + porcelana (recobrimento); Estudo B ­ DL+LEU (dissilicato de lítio + leucita), LEU+DL (leucita + dissilicato de lítio), CH+DL (cerâmica híbrida + dissilicato de lítio) e CH+LEU (cerâmica híbrida + leucita). Para o Estudo A, todas as infraestruturas foram usinadas; os recobrimentos dos grupos IC e IME foram confeccionados através da estratificação, e os recobrimentos do grupo IMC foram usinados. Já para o Estudo B, todas as peças foram usinadas, de acordo com o material cerâmico de cada grupo. Em seguida, foi realizada a cimentação adesiva dos recobrimentos sobre as infraestruturas (a depender do grupo) e das coroas sobre os preparos utilizando cimento resinoso fotopolimerizável (Variolink Esthetic LC). Após a cimentação, os espécimes foram submetidos ao teste de fadiga cíclica (10.000 ciclos, 20Hz), e como desfecho foram considerados dois eventos, em que o primeiro foi a ocorrência de trinca e/ou lascamento (evento 1) e o segundo foi a falha catastrófica do conjunto (evento 2). Os valores de carga e número de ciclos para falha em que foram observados os eventos 1 e 2 foram utilizados para realizar a análise de sobrevivência de acordo com Kaplan-Meier e Log-Rank (Mantel-Cox; 95%). As marcas de fratura e o modo de falha das coroas foram avaliados e classificados por estereomicroscópio óptico e microscópio eletrônico de varredura. Por fim, foi realizada análise por elementos finitos (FEA) para ambos os estudos, a fim de avaliar a distribuição de tensões sobre as coroas e interface adesiva. Para o Estudo A, os resultados do teste de fadiga mostraram que, considerando o evento 1 (trinca/lascamento), os grupos IC e IMC apresentaram médias de carga fadiga estatisticamente significantes entre si (733,33 N e 913,33 N, respectivamente), enquanto o grupo IME apresentou média superior (1.020 N). O mesmo foi observado para o número de ciclos em fadiga para todos os grupos. Ao considerar o evento 2 (falha catastrófica), os três grupos apresentaram médias estatisticamente semelhantes entre si (~1.028 N). Os resultados de FEA mostraram que o grupo IC concentrou maior tensão de tração do que os grupos IME e IMC. Para o Estudo B, no teste de fadiga, o grupo DL+LEU apresentou a maior média de resistência à fadiga (evento 1: 913,33 N e evento 2: 1033,33 N), enquanto todas as outras combinações de materiais cerâmicos analisadas foram estatisticamente semelhantes entre si, considerando carga e número de ciclos. Com relação ao FEA, os grupos com cerâmica híbrida (CH+DL e CH+LEU) apresentaram menores picos de concentração de tensão na infraestrutura do que os grupos com cerâmicas vítreas (DL+LEU e LEU+DL), porém, em contrapartida, concentraram maior tensão na interface adesiva. Com isso, conclui-se que a utilização da infraestrutura modificada é uma alternativa viável e promissora para tratamentos reabilitadores, apresentando sobrevivência em fadiga e distribuição de tensões satisfatórias. Além disso, a combinação entre uma infraestrutura de dissilicato de lítio e recobrimento de cerâmica a base de leucita corresponde a melhor abordagem considerando a infraestrutura modificada.(AU)

The objective of this study was to evaluate the biomechanical behavior through fatigue resistance and finite element analysis of bilaminar bioinspired crowns with modified infrastructures on the buccal surface (Study A) and using different ceramic materials with different elastic moduli (Study B). For this, 90 preparations were made for a full crown in G10 epoxy resin, on which bioinspired crowns were prepared according to the following groups: Study A - CI (conventional infrastructure), SMI (stratified modified infrastructure) and CMI (cemented modified infrastructure ), all made of lithium disilicate (infrastructure) + porcelain (veneer); Study B ­ LD+LEU (lithium disilicate + leucite), LEU+LD (leucite + lithium disilicate), HC+LD (hybrid ceramic + lithium disilicate) and HC+LEU (hybrid ceramic + leucite). For Study A, all infrastructures were machined; the coverings of the CI and SMI groups were made through stratification technique, and the veneers of the SMI group were machined. For Study B, all pieces were machined, according to the ceramic material of each group. Then, the veneers were cemented into their infrastructures (depending on the group) and crowns were cemented into preparations using light-cured resin cement (Variolink Esthetic LC). After cementing, the specimens were subjected to the cyclic fatigue test (10,000 cycles, 20Hz), and as an outcome two events were considered: the occurrence of cracking and/or chipping (event 1) and catastrophic failure (event 2). The load (N) and number of cycles to failure in which events 1 and 2 were observed were used to perform the survival analysis according to Kaplan-Meier and Log-Rank (Mantel- Cox; 95%). The fracture marks and failure mode of the crowns were evaluated and classified by optical stereomicroscope and scanning electron microscope. Finally, finite element analysis (FEA) was performed for both studies in order to evaluate the stress distribution over the crowns and adhesive interface. For Study A, the results of the fatigue test showed that, considering event 1 (cracking/chipping), the CI and CMI groups presented average to failure that were statistically significant compared to each other (733.33 N and 913.33 N, respectively), while the SMI group showed higher averages (1,020 N). Same pattern was observed for the number of cycles under fatigue for both groups. When considering event 2 (catastrophic failure), the three groups presented statistically similar means (~1,028 N). The FEA results showed that the CI group concentrated greater tensile stress than the CMI and SMI groups. For Study B, in the fatigue test, the LC+LEU group presented the highest average fatigue resistance (event 1: 913.33 N and event 2: 1033.33 N), while all other combinations of ceramic materials analyzed were statistically similar to each other, considering load and number of cycles. Regarding FEA, the groups with hybrid ceramics (HC+LC and HC+LEU) showed lower stress concentration peaks in the infrastructure than the groups with glass ceramics (LC+LEU and LEU+LC), however, on the other hand, concentrated greater tension at the adhesive interface. With this, it is concluded that the use of modified infrastructure is a viable and promising alternative for oral rehabilitation treatments, presenting satisfactory fatigue survival and adequate stress distribution. Furthermore, the combination of a lithium disilicate infrastructure and a leucite-based ceramic coating corresponds to the best approach considering the modified infrastructure.(AU)

Significados atribuídos por mulheres com câncer de mama ao grupo de apoio / Meanings attributed by women with breast cancer to a support group / Significados atribuidos por las mujeres con cáncer de mama al grupo de apoyo

A sobrevivência ao câncer de mama é um problema de saúde pública que demanda serviços especializados com foco na reabilitação psicossocial. Entre as necessidades identificadas nesse contexto está o incentivo à adoção de estratégias de promoção de autocuidados pelas mulheres. Uma das estratégias adotadas consiste no grupo de apoio psicológico, que auxilia as pacientes a enfrentar a longa jornada do tratamento. Assim, o objetivo deste estudo é compreender os significados produzidos por mulheres com câncer de mama sobre sua participação em um grupo de apoio. Trata-se de um estudo qualitativo, descritivo e exploratório realizado com dez mulheres com câncer de mama usuárias de um serviço de reabilitação para mastectomizadas. Como referencial metodológico foi utilizada a Teoria Fundamentada nos Dados. A coleta de dados foi realizada por meio de entrevista aberta em profundidade e os conteúdos foram transcritos e codificados. A análise indutiva e o método de comparação constante foram aplicados nos processos de codificação aberta, axial e seletiva, que permitiram identificar três categorias nucleares: percepção das atividades realizadas no grupo, identificação de benefícios e barreiras do convívio no grupo e transformações decorrentes da participação. As participantes significaram sua presença no grupo como fonte de acolhimento, apoio, desenvolvimento de recursos pessoais e amizades, contribuindo para promover sua qualidade de sobrevida. Além dos potenciais benefícios, também foram identificadas barreiras que podem dificultar a adesão e continuidade da participação no grupo, o que sugere a necessidade de incorporar no cuidado um olhar para as dimensões subjetivas da saúde da mulher.(AU)

Surviving breast cancer is a public health problem and depends on services focused on psychosocial rehabilitation. Healthcare providers must encourage women to adopt strategies to promote their self-care. The psychological support group is a resource that helps women to face the long journey of treatment. This study aimed to understand the meanings women with breast cancer produced about their participation in a support group. This exploratory cross-sectional study was carried out with 10 women with breast cancer who use a rehabilitation service for mastectomized patients. Grounded Theory was used as a methodological reference. An open in-depth interview was applied for data collection. The contents were transcribed and coded. Inductive analysis and the constant comparison method were applied in the open, axial, and selective coding processes, which enabled the identification of three core categories: perception of the activities carried out in the group, identification of benefits and barriers of living in the group, and transformations resulting from participation. Participants denote their involvement with the group as a source of shelter, support, development of personal resources and friendships that helps promoting quality of life. Besides these potential benefits, participants also evinced barriers that can hinder adherence and continuity of participation in the group, suggesting the importance of incorporating a look at the subjective dimensions of women's health into care.(AU)

Sobrevivir al cáncer de mama es un problema de salud pública que depende de los servicios centrados en la rehabilitación psicosocial. Entre las necesidades identificadas en esta materia se encuentra el uso de estrategias para promover el autocuidado. Uno de los recursos que ayuda a afrontar el largo camino del tratamiento es el grupo de apoyo psicológico. El objetivo de este estudio es conocer los significados que producen las mujeres con cáncer de mama sobre su participación en un grupo de apoyo. Se trata de un estudio cualitativo, descriptivo y exploratorio, realizado con diez mujeres con cáncer de mama usuarias de un servicio de rehabilitación para mastectomizadas. Como referencia metodológica se utilizó la teoría fundamentada en los datos. Se aplicó una entrevista abierta en profundidad para la recogida de datos, cuyos contenidos fueron transcritos y codificados. El análisis inductivo y el método de comparación constante se aplicaron en los procesos de codificación abierta, axial y selectiva, lo que permitió identificar tres categorías centrales: percepción de las actividades realizadas en el grupo, identificación de los beneficios y las barreras de vivir en el grupo y transformaciones resultantes de la participación. Las mujeres denotan su participación en el grupo como una fuente de acogida, apoyo, desarrollo de recursos personales y amistades, que ayuda a promover la calidad de vida. Además de los beneficios potenciales, también se identificaron barreras que pueden dificultar la adherencia y continuidad de la participación en el grupo, lo que sugiere la necesidad de incorporar en la atención una mirada centrada en las dimensiones subjetivas de la salud de las mujeres.(AU)

A fase terminal do filho com câncer: percepções dos profissionais hospitalares / The terminal phase of children with cancer: perceptions of hospital professionals / La fase terminal del hijo con cáncer: percepciones de los profesionales del hospital

O confronto com o câncer de um filho e a percepção da sua morte como inevitável dão lugar a experiências parentais relevantes para a pesquisa científica. Este estudo teve como objetivo investigar, por meio da percepção dos profissionais hospitalares, o modo como os pais experienciam a fase terminal e fim de vida do filho com câncer para melhor compreender os processos psicoemocionais experienciados por esses pais diante da cronicidade da doença e da morte do filho. No sentido de alcançar esse objetivo, realizou-se um estudo qualitativo de tipo fenomenológico envolvendo 17 profissionais de dois hospitais portugueses de referência em oncologia pediátrica. Os dados foram recolhidos com recurso a um guia de entrevista semiestruturada. Na percepção dos profissionais hospitalares, os resultados evidenciam que esses pais experienciam múltiplas dificuldades e preocupações na fase terminal da doença do filho e no pós-morte, bem como um sofrimento extremo e desestruturação biopsicossocial e espiritual na família. O conhecimento aprofundado da fenomenologia desses processos é essencial para o desenho e a implementação de intervenções emocionais, cognitivas, comportamentais e sociais mais ajustadas às dificuldades e preocupações parentais vividas no fim de vida e pós-morte.(AU)

Coping with children's cancer and the perception of their inevitable death give rise to parental experiences that are important to study. This study aimed to investigate, based on hospital professionals' perspectives, how parents experience the terminal phase and end of life of their children suffering from cancer to better understand the psycho-emotional processes these parents experienced in face of the chronicity of the disease and their children's death. To achieve this objective, a qualitative phenomenological study was carried out involving 17 professionals of two Portuguese hospitals that are reference in pediatric oncology. Data were collected using a semi-structured interview guide. From the perspective of hospital professionals, results show that these parents experience multiple difficulties and concerns in the terminal phase of their children's disease and postmortem, as well as the extreme suffering and biopsychosocial and spiritual disruption of the family. A deeper understanding of the phenomenology of these processes is essential to design and implement better adjusted emotional, cognitive, behavioral, and social interventions aimed at the parental difficulties and concerns experienced at the end of life and after death.(AU)

El enfrentamiento del cáncer de un hijo y la percepción de su muerte como inevitable dan lugar a experiencias parentales importantes que deben ser estudiadas. Este estudio pretende identificar desde la percepción de los profesionales del hospital cómo los padres viven la fase terminal y el final de la vida de su hijo con cáncer con el fin de comprender mejor los procesos psicoemocionales que viven estos padres ante la cronicidad de la enfermedad y la muerte de su hijo. Para ello, se realizó un estudio cualitativo, con enfoque fenomenológico, en el que participaron 17 profesionales de dos hospitales portugueses de referencia en oncología pediátrica. Para recoger los datos se aplicó un guion de entrevista semiestructurada. En cuanto a la percepción de los profesionales del hospital, estos padres experimentaron múltiples dificultades y preocupaciones en la fase terminal de la enfermedad de su hijo y postmuerte, así como un sufrimiento extremo y una desestructuración biopsicosocial y espiritual en la familia. El conocimiento en profundidad de la fenomenología de estos procesos es esencial para elaborar e implementar intervenciones emocionales, cognitivas, conductuales y sociales más acordes a las dificultades y preocupaciones parentales que se experimentan al final de la vida y la postmuerte.(AU)

Flavonoides como suplementos para mejorar el rendimiento físico deportivo / Flavonoids as Supplements to Improve Sports Physical Performance

Introducción: El ejercicio físico puede generar especies reactivas de oxígeno que dañan componentes celulares esenciales, como la fatiga. Los flavonoides, debido a su baja toxicidad y actividad antioxidante, se han estudiado como potenciales suplementos alimenticios para mejorar el rendimiento deportivo. Objetivo: Describir la evidencia científica que se ha obtenido sobre la eficacia del uso de flavonoides como suplementos para mejorar el rendimiento físico deportivo. Métodos: Se realizó una búsqueda sobre la eficacia del uso de flavonoides como suplementos para el rendimiento físico y deportivo en las bases de datos PubMed y Google Scholar. Se utilizaron las palabras clave: flavonoid, supplementation, sport, exercise, fatigue, muscle, fats, physical activity, y se tomaron en cuenta los artículos publicados entre los años 2018 y 2022, en idioma inglés que cumplieron con los criterios de selección. Resultados: Los flavonoides son capaces de disminuir la fatiga debido al esfuerzo físico en un contexto deportivo, principalmente debido a su capacidad de regular la actividad de agentes antioxidantes endógenos como las enzimas superóxido dismutasa, catalasa y glutatión peroxidasa, que se encargan de la neutralización de las especies reactivas de oxígeno. Además, son capaces de favorecer la neutralización de metabolitos tóxicos que se generan durante el ejercicio y de aumentar las reservas energéticas (glicógeno en el hígado y músculos) y la resistencia muscular. Conclusiones: Existe evidencia científica de que los flavonoides son capaces de mejorar el rendimiento físico deportivo principalmente al disminuir la fatiga e incrementar la resistencia muscular(AU)

Introduction: Physical exercise can generate reactive oxygen species that damage essential cellular components, such as fatigue. Flavonoids, due to their low toxicity and antioxidant activity, have been studied as potential dietary supplements to improve sports performance. Objective: To describe the scientific evidence that has been obtained on the efficacy of the use of flavonoids as supplements to improve sports physical performance. Methods: A search was carried out, in PubMed and Google Scholar databases, on the efficacy of the use of flavonoids as supplements for physical and sports performance. The keywords were used flavonoid, supplementation, sport, exercise, fatigue, muscle, fats, physical activity. Articles published from 2018 to 2022, in English, that met the selection criteria were taken into account. Results: Flavonoids are capable of reducing fatigue due to physical exertion in a sports context, mainly due to their ability to regulate the activity of endogenous antioxidant agents such as superoxide dismutase, catalase and glutathione peroxidase enzymes, which are responsible for the neutralization of reactive oxygen species. In addition, they are capable of favoring the neutralization of toxic metabolites that are generated during exercise and of increasing energy reserves (glycogen in the liver and muscles) and muscular resistance. Conclusions: There is scientific evidence that flavonoids are capable of improving sports physical performance, mainly by reducing fatigue and increasing muscular resistance(AU)

The association Between Sleep Quality, Fatigue and Periodontal Status: a pilot study / La asociación entre la calidad del sueño, la fatiga y el estado periodontal: un estudio piloto

Abstract Reduced sleep duration, poor sleep quality and fatigue are related to reduced immunity and increased inflammatory markers. Due to its potential to influence inflammation, poor sleep quality and fatigue could be factors for periodontitis and quality of life. Ninety-three individuals with untreated periodontitis and thirty-one individuals with healthy gingiva were included in the study. The research involved a clinical examination and a questionnaire. Demographic information, information on oral health, oral hygiene habits, the Pittsburgh Sleep Quality Index, Jenkins Sleep Scale, Multidimensional Assessment of Fatigue Scale, and Oral Health Impact Profile-14 were included in the questionnaire. Patients were diagnosed based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. No statistically significant difference was revealed between sleep quality, fatigue, oral health related quality of life, and stage-grade of periodontitis (p<0.05). However, periodontitis group had higher Oral Health Impact Profile-14 scores (p<0.05). A statistically significantly lower sleep duration was observed in stage IV periodontitis group than the other groups (p<0.05). A statistically significant positive correlation was observed between the Pittsburgh Sleep Quality Index and the scores of the other questionnaires (p<0.05). The stage of periodontitis may impact sleep duration.

Resumen La reducción de la duración del sueño, la mala calidad del sueño y la fatiga están relacionados con una inmunidad reducida y un aumento de los marcadores inflamatorios. Debido a su potencial para influir en la inflamación, la mala calidad del sueño y la fatiga podrían ser factores determinantes en el desarrollo de la periodontitis e incidir en la calidad de vida. Noventa y tres personas con periodontitis no tratada, además de treinta y una personas con encía sana se incluyeron en el estudio. La investigación involucró un examen clínico y un cuestionario. En el cuestionario se incluyeron información demográfica, información sobre salud bucal, hábitos de higiene bucal, el índice de calidad del sueño de Pittsburgh, la escala de sueño de Jenkins, la escala de evaluación multidimensional de la fatiga y el perfil de impacto en la salud bucal-14. Los pacientes fueron diagnosticados en base al Taller Mundial 2017 sobre la Clasificación de Enfermedades y Condiciones Periodontales y Periimplantarias. No se revelaron diferencias estadísticamente significativas entre la calidad del sueño, la fatiga, la calidad de vida relacionada con la salud bucal y el grado de etapa de la periodontitis (p<0,05). Sin embargo, el grupo de periodontitis tuvo puntajes más altos en el Perfil de Impacto en la Salud Oral-14 (p<0.05). Se observó una duración del sueño significativamente menor desde el punto de vista estadístico en el grupo de periodontitis en estadio IV que en los otros grupos (p<0,05). Se observó una correlación positiva estadísticamente significativa entre el Índice de Calidad del Sueño de Pittsburgh y las puntuaciones de los otros cuestionarios (p<0,05). La etapa de la periodontitis puede afectar la duración del sueño.

El efecto de la reflexología podal sobre la fatiga en pacientes en hemodiálisis: un estudio de metaanálisis / The effect of foot reflexology on fatigue in hemodialysis patients: a meta-analysis study / O efeito da reflexologia podal sobre a fadiga em pacientes em hemodiálise: um estudo de metanálise

Objetivo: analizar el efecto de la reflexología podal sobre la fatiga en pacientes en hemodiálisis, combinando los resultados de estudios independientes sobre este tema. Método: estudio de metaanálisis. Se realizó una búsqueda bibliográfica en siete bases de datos. La calidad metodológica de los estudios incluidos se evaluó mediante las herramientas propuestas por el Joanna Briggs Institute. Para el metaanálisis se utilizó el programa Comprehensive Meta-Analysis v3. Resultados: en el metaanálisis se incluyeron ocho estudios. El resultado de la diferencia de medias estandarizada del metaanálisis = 1,580 (Intervalo de Confianza de 95% = 1,075 - 2,085 p = 0,000). El resultado del análisis de subgrupos realizado sobre la base de la diferencia de medias estandarizada en el número de sesiones de reflexología podal = 1,478 (Intervalo de Confianza de 95% = 1,210 - 1,747, p = 0,000). Conclusión: se concluyó que la reflexología podal puede utilizarse para reducir la fatiga en pacientes en hemodiálisis. En los estudios investigados no se proporcionó información sobre los posibles efectos secundarios y negativos de la reflexología podal.

Objective: this meta-analysis study analyzed the effect of foot reflexology on fatigue in hemodialysis patients by combining the results of independent studies on this subject. Method: meta-analysis study. A literature search was conducted in seven databases. The methodological quality of the included studies was assessed using tools proposed by the Joanna Briggs Institute. Comprehensive Meta-Analysis v3 was used for meta-analysis. Results: eight studies were included in the meta-analysis. The result of the meta-analysis standardized mean difference = 1.580 (95% Confidence Interval = 1.075 - 2.085 p = 0.000). The result of the subgroup analysis performed based on the number of foot reflexology sessions standardized mean difference = 1,478 (95% Confidence Interval = 1,210 - 1,747, p = 0.000). Conclusion: it was concluded that foot reflexology can be used to reduce fatigue in hemodialysis patients. No information was provided in the investigated studies about the possible side effects and negative effects of foot reflexology.

Objetivo: analisar o efeito da reflexologia podal sobre a fadiga em pacientes em hemodiálise, combinando os resultados de estudos independentes sobre este assunto. Método: estudo de metanálise. Foi realizada uma pesquisa bibliográfica em sete bases de dados. A qualidade metodológica dos estudos incluídos foi avaliada por meio de ferramentas propostas pelo Joanna Briggs Institute. Para a metanálise, foi utilizado o Comprehensive Meta-Analysis v3. Resultados: oito estudos foram incluídos na metanálise. O resultado da diferença média padronizada da metanálise = 1,580 (Intervalo de Confiança de 95% = 1,075 - 2,085 p = 0,000). O resultado da análise de subgrupo realizada com base na diferença média padronizada do número de sessões de reflexologia podal = 1,478 (Intervalo de Confiança de 95% = 1,210 - 1,747, p = 0,000). Conclusão: a reflexologia podal pode ser utilizada para reduzir a fadiga em pacientes em hemodiálise. Não foram fornecidas informações nos estudos investigados sobre os possíveis efeitos colaterais e negativos da reflexologia podal.

Solidão e sobrecarga materna em tempos de pandemia de COVID-19 à luz da escuta psicanalítica dos vínculos / Loneliness and maternal burden of care in times of COVID-19 pandemic in the light of psychoanalytic listening to bonds / Soledad y sobrecarga materna en tiempos de pandemia COVID-19 a la luz de la escucha psicoanalítica de los vínculos

Este estudo teve por objetivo analisar o impacto do confinamento doméstico provocado pela pandemia de COVID-19 sobre o exercício da maternidade em mulheres trabalhadoras em situação de home office. Trata-se de um estudo exploratório, com delineamento longitudinal e referencial teórico da psicanálise dos vínculos. Entre abril e julho de 2020 foram realizadas entrevistas on-line com 20 mães de camadas sociais médias, de 29 a 45 anos. Um ano depois foram realizadas novas entrevistas com 10 participantes, todas transcritas e analisadas por meio da análise temática. Os resultados apontaram que, em comparação com o período inicial da pandemia, as mães mostraram-se próximas do esgotamento físico e psíquico devido ao excesso de trabalho contínuo e falta de apoio social e familiar, com impactos deletérios na saúde mental das participantes, relatos de sofrimento e desamparo psicológico. A busca pela medicalização revela uma percepção individualizada do problema e uma tentativa de demonstrar estoicismo para atenuar o sofrimento decorrente dessa experiência. (AU)

This study aimed to analyze how domestic confinement resulting from the COVID-19 pandemic impacted motherhood among working women in a home office situation. This was an exploratory study, employing a longitudinal design and the theoretical framework of the psychoanalysis of bonds. Between April and July 2020, online interviews were conducted with 20 mothers from middle social strata, aged 29 to 45. One year later, new interviews were conducted with 10 participants, all transcribed and subjected to thematic analysis. The results showed that, compared to the initial period of the pandemic, mothers were close to physical and psychological exhaustion due to continuous overwork and lack of social and family support. These factors had deleterious impacts on the participants' mental health, leading to reports of suffering and psychological helplessness. The search for medicalization reveals an individualized perception of the problem and an attempt to demonstrate stoicism to mitigate the suffering resulting from this experience. (AU)

Este estudio tuvo como objetivo analizar el impacto del confinamiento doméstico debido a la pandemia de COVID-19 en la maternidad de mujeres trabajadora en situación de teletrabajo. Se trata de un estudio exploratorio, con diseño longitudinal y marco teórico del psicoanálisis de los vínculos. Entre abril y julio de 2020 se realizaron entrevistas online a 20 madres de clases sociales medias, de 29 a 45 años; un año después, se realizaron nuevas entrevistas con 10 participantes. Las entrevistas fueron transcritas y analizadas mediante análisis temático. Los resultados mostraron que, en comparación con el período inicial de la pandemia, las madres experimentaron un acercamiento al agotamiento físico y psicológico por el exceso de trabajo y la falta de apoyo social y familiar, con impactos deletéreos en la salud mental de las participantes, relatos de sufrimiento e impotencia psicológica. La búsqueda de la medicalización revela una percepción individualizada del problema y un intento de demostrar estoicismo para aliviar el sufrimiento resultante de esta experiencia. (AU)

Características clínicas, diagnóstico e tratamento de mulher com síndrome de Meigs: relato de caso e revisão narrativa / Clinical characteristics, diagnosis and treatment of a woman with Meigs syndrome: case report and narrative review

O objetivo deste estudo é descrever o caso de mulher com síndrome de Meigs e apresentar a revisão narrativa sobre o tema. Paciente do sexo feminino, 30 anos, nulípara, encaminhada ao hospital por massa anexial e história prévia de drenagem de derrame pleural. Evoluiu com instabilidade hemodinâmica por derrame pleural hipertensivo à direita, sendo submetida a drenagem torácica, com citologia do líquido negativa. Após, foi submetida a laparotomia: realizada salpingo-ooforectomia esquerda. A congelação e a análise histopatológica diagnosticaram fibroma ovariano. A citologia ascítica foi negativa. CA-125 elevado, presença de derrames cavitários e exame de imagem suspeito podem mimetizar um cenário de neoplasia maligna de ovário em estágio avançado. Entretanto, na síndrome de Meigs clássica, o tratamento é cirúrgico, sendo o diagnóstico obtido por meio da análise histopatológica do tumor ovariano. O manejo da síndrome de Meigs clássica é cirúrgico e, após a remoção do tumor, o derrame pleural e a ascite desaparecem.

To describe a case of Meigs syndrome and present a narrative review of the condition. Female patient, 30 years old, nulliparous, referred to the hospital due to an adnexal mass and a previous drainage of pleural effusion. She developed hemodynamic instability due to a hypertensive right pleural effusion being submitted to chest drainage, with negative cytology of the fluid. She underwent laparotomy: Left salpingo-oophorectomy was performed and frozen section and histopathological analysis diagnosed an ovarian fibroma. Ascites cytology was negative. Elevated CA-125, presence of cavitary effusions, suspicious imaging exam can mimic a scenario of ovarian cancer at an advanced stage. However, in classical Meigs syndrome, treatment is surgical, and the diagnosis is obtained through histopathological analysis of the ovarian tumor. Classical Meigs syndrome' management is surgical. After tumor removal, pleural effusion and ascites resolve.

Fear and Coping with Death in Intensive Care Nurses: a Structural Model Predictor of Compassion Fatigue / Miedo y afrontamiento ante la muerte del usuario: un modelo estructural predictor de la fatiga por compasión en enfermeros de cuidados intensivos / Medo e enfrentamento da morte do usuário: um modelo estrutural preditivo da fadiga por compaixão em enfermeiros de terapia intensiva

Objective. To determine the effect of fear and coping with death on compassion fatigue in nurses working in the intensive care unit. Methods. Correlational-predictive design, applied in 245 nurses working in the intensive care unit through intentional sampling. The study applied a personal data card, the Collet-Lester Fear of Death Scale (α=0.72), the Bugen Fell of Death Scale (α=0.82), and the Empathy Exhaustion Scale (α=0.80). Descriptive and inferential statistics were performed, such as Spearman's test and a structural equation model. Results. The work had 255 nurses who participated, finding a relationship among fear and coping toward death and compassion fatigue (p<0.01), together with the equation model showing that fear and coping toward death have a positive effect in 43.6% on compassion fatigue. Conclusion. Fear and coping with death have an effect on compassion fatigue in nurses working in the intensive care unit, so that when working in a critical area it can cause health effects

Objetivo. Determinar el efecto del miedo y afrontamiento ante la muerte sobre la fatiga por compasión en enfermeros que laboran en la unidad cuidados intensivos. Método. Diseño correlacional-predictivo. A través de un muestreo intencional se seleccionaron 255 enfermeros que laboraban en Unidades de Cuidados Intensivos de Adultos de hospitales de la Península de Yucatán (México). Se aplicó una cédula de datos personales, la escala de miedo a la muerte de Collet-Lester (α=0.72), la escala de Bugen de afrontamiento de la muerte (α=0.82) y la escala de agotamiento por empatía (α=0.80). Se realizó estadística descriptiva e inferencial como prueba de Spearman y un modelo de ecuación estructural. Resultados. Se encontró relación del miedo y el afrontamiento hacia la muerte con la fatiga por compasión (p<0.01). Adicionalmente, el modelo de ecuaciones muestra que el miedo y el afrontamiento hacia la muerte predice en un 43.6% sobre la fatiga por compasión. Conclusión. El miedo y el afrontamiento hacia la muerte tienen efecto sobre la fatiga por compasión en los enfermeros que laboran en la unidad de cuidados intensivos, por lo que al estar laborando en esta área crítica puede provocar afectaciones en su estado de salud.

Objetivo. Determinar o efeito do medo e enfrentamento da morte na fadiga por compaixão em enfermeiros que atuam em Unidade de Terapia Intensiva (UTI). Métodos. Desenho preditivo correlacional. Por meio de amostragem intencional, foram selecionados 255 enfermeiros que trabalhavam em Unidades de Terapia Intensiva de Adultos de hospitais da Península de Yucatán (México). Foi aplicada uma ficha de dados pessoais, a escala de medo da morte de Collet -Lester (α=0.72), a escala de Bugen de enfrentamento da morte (α=0.82) e a escala de exaustão por empatia (α=0.80). Foram realizadas estatísticas descritivas e inferenciais como o teste de Spearman e um modelo de equação estrutural. Resultados. Encontrou-se relação entre medo e enfrentamento da morte e fadiga por compaixão (p<0.01). Além disso, o modelo de equação mostra que o medo e o enfrentamento da morte preveem 43.6% da fadiga por compaixão. Conclusão. O medo e o enfrentamento da morte afetam a fadiga por compaixão em enfermeiros que atuam em UTI, portanto, trabalhar nessa área crítica pode afetar seu estado de saúde.

Assessment of responsiveness and minimum important difference of the Maternal perception of Childbirth Fatigue Questionnaire (MCFQ) / Avaliação da responsividade e diferença mínima importante do Questionário de percepção Materna de Fadiga no trabalho de Parto (QMFP)

INTRODUCTION: The assessment of responsiveness and the Minimum Clinically Important Difference (MCID) is the basis for validating the Maternal perception of Childbirth Fatigue Questionnaire (MCFQ). OBJECTIVE: To assess the responsiveness and determine the value of the MCID for the MCFQ. METHODS: This is an observational study, conducted at HC-UFPE with 50 parturients in active labor. The MCFQ was applied in two moments: in the initial evaluation (EV1), performed at the beginning of labor between 4-6 cm of uterine dilation, and final (EV2), six hours after the first evaluation. Responsiveness was determined by calculating the effect size (ES), and standardized response mean (SRM), considering that values of 0.2, 0.5, and 0.8 points represent respectively small, moderate, or large values of responsiveness. The ability to detect change through the questionnaire was also assessed by the t-test. The level of significance adopted for this analysis was p less than 0.05. The MCID was verified based on the calculation of the standard error of measurement (SEM) index. RESULTS: The MCFQ showed values of 0.4 and 0.6 for ES and SEM respectively and a p-value <0.001, thus showing a good capacity for change. The value of the MCID for this population was seven points. CONCLUSION: MCFQ presents a potentially significant change with a value of the MCID of seven points after six hours of active labor.

INTRODUÇÃO: A avaliação da responsividade e da Diferença Mínima Importante (DMI) é fundamentação para validação do Questionário de percepção Materna de Fadiga no Trabalho de Parto (QMFP). OBJETIVO: Avaliar a responsividade e determinar o valor da DMI para o QMFP. MÉTODOS: Trata-se de um estudo observacional, realizado no HC-UFPE com 50 parturientes em fase ativa do trabalho de parto. O QMFP foi aplicado em dois momentos: na avaliação inicial (AV1), realizada no início do trabalho de parto entre 4-6 centímetro de dilatação uterina, e final (AV2), após seis horas da primeira avaliação. A responsividade foi determinada pelo cálculo do effect size (ES), standardized response mean (SRM), considerando que valores de 0,2, 0,5 e 0,8 pontos representam respectivamente um pequeno, moderado ou grande valor de responsividade. A capacidade de detectar mudança pelo questionário também foi avaliada pelo test t. O nível de significância adotado para essa análise foi p menor que 0,05. A DMI foi verificada com base no cálculo do índice standard error of measurement (SEM). RESULTADOS: O QMFP apresentou valores de 0,4 e 0,6 de ES e SEM respectivamente e valor de p<0,001, logo apresenta uma boa capacidade de mudança. O valor da DMI para esta população foi de sete pontos. CONCLUSÃO: O QMFP apresenta uma mudança potencialmente significativa com um valor da DMI de sete pontos após seis horas de trabalho de parto ativo.

Clinical characteristics of COVID-19 Omicron variant infection in children with allergic diseases / 中华预防医学杂志

Objective: To analyze the clinical characteristics of infection of COVID-19 Omicron variants in children with allergic diseases. Methods: This was a cross-sectional retrospective study. A total of 657 pediatric patients with allergic diseases aged between 0-17 years confirmed with COVID-19 infection were enrolled from the Children's Hospital affiliated to Capital Institute of Pediatrics from January to March 2023. The median age was 6.6(4.7,9.9) years, with 443 males (67.4%) and 214 females (32.6%). Demographic data, vaccination status, clinical manifestations, therapeutic drugs, and other data were collected. The patients were then divided into different groups according to the age, type of allergic diseases and vaccination status, and their clinical characteristics were compared. Results: A total of 657 children with allergic diseases were included in this study, among them 568 with asthma. Fever is the most common symptoms after COVID-19 infection (627/657, 95.4%), and 509 children (77.5%) with high fever. Cough was observed in 446 (67.9%) and fatigue in 167 (25.4%) cases.10 cases (1.5%) were diagnosed as pneumonia. The proportion of pharyngalgia(22%,84/382, χ2=19.847, P<0.01), fatigue (31.7%, 121/382,χ2=23.831, P<0.01), headache(34.6%, 132/382,χ2=57.598, P<0.01), muscle joint pain(16.0%, 61/382,χ2=22.289, P<0.01) and vomiting(11.0%, 42/382,χ2=12.756, P<0.01) were highest in the>6 years group. Children younger than 3 years had the lowest proportion of runny nose(8.8%, 5/57,χ2=8.411, P<0.01), cough(45.6%, 26/57,χ2=6.287, P<0.05) and expectoration(7.0%, 4/57,χ2=5.950, P<0.05). 62.8%(137/218) of the patients in 3-6 year group had the highest rate of cough(χ2=6.287, P<0.05), with a higher proportion of wheezing (10.1%, 22/218). Cough and/or wheezing symptoms were most quickly relieved in the 6 year old group, who had a highest proportion of 68.8%(260/382) in duration of respiratory symptoms within 1 week compared with 52.2% (114/218)of 3-6 years group and 41.2% (22/57)of<3 year group, respectively(χ2=23.166, P<0.01). The asthma group had a significant higher proportion of cough(59.7% vs 41.6%, χ2=10.310, P<0.01), wheezing (8.5% vs 0.0%, χ2=8.114, P<0.01) and expectoration (19.2% vs 7.9%, χ2=10.310, P<0.01) than that of non-asthma group. Besides, patients with cough and/or wheezing in the asthma group had more impact on exercise and sleep (16.1% vs 0, χ2=5.436, P<0.05) and a longer duration over 4 weeks (25.1% vs 3.7%, χ2=6.244, P<0.05). Conclusions: The most common symptoms in children with allergy infected with COVID-19 Omicron variant were fever and cough. Children under 3 years of age had relatively fewer respiratory symptoms while those with asthma or aged 3-6 years were more likely to have cough and wheezing and longer duration of symptoms. The data suggested that the prevention and management of COVID-19 should be strengthened in children with allergy.

Clinical characteristics of COVID-19 Omicron variant infection in children with allergic diseases / 中华预防医学杂志

Objective: To analyze the clinical characteristics of infection of COVID-19 Omicron variants in children with allergic diseases. Methods: This was a cross-sectional retrospective study. A total of 657 pediatric patients with allergic diseases aged between 0-17 years confirmed with COVID-19 infection were enrolled from the Children's Hospital affiliated to Capital Institute of Pediatrics from January to March 2023. The median age was 6.6(4.7,9.9) years, with 443 males (67.4%) and 214 females (32.6%). Demographic data, vaccination status, clinical manifestations, therapeutic drugs, and other data were collected. The patients were then divided into different groups according to the age, type of allergic diseases and vaccination status, and their clinical characteristics were compared. Results: A total of 657 children with allergic diseases were included in this study, among them 568 with asthma. Fever is the most common symptoms after COVID-19 infection (627/657, 95.4%), and 509 children (77.5%) with high fever. Cough was observed in 446 (67.9%) and fatigue in 167 (25.4%) cases.10 cases (1.5%) were diagnosed as pneumonia. The proportion of pharyngalgia(22%,84/382, χ2=19.847, P<0.01), fatigue (31.7%, 121/382,χ2=23.831, P<0.01), headache(34.6%, 132/382,χ2=57.598, P<0.01), muscle joint pain(16.0%, 61/382,χ2=22.289, P<0.01) and vomiting(11.0%, 42/382,χ2=12.756, P<0.01) were highest in the>6 years group. Children younger than 3 years had the lowest proportion of runny nose(8.8%, 5/57,χ2=8.411, P<0.01), cough(45.6%, 26/57,χ2=6.287, P<0.05) and expectoration(7.0%, 4/57,χ2=5.950, P<0.05). 62.8%(137/218) of the patients in 3-6 year group had the highest rate of cough(χ2=6.287, P<0.05), with a higher proportion of wheezing (10.1%, 22/218). Cough and/or wheezing symptoms were most quickly relieved in the 6 year old group, who had a highest proportion of 68.8%(260/382) in duration of respiratory symptoms within 1 week compared with 52.2% (114/218)of 3-6 years group and 41.2% (22/57)of<3 year group, respectively(χ2=23.166, P<0.01). The asthma group had a significant higher proportion of cough(59.7% vs 41.6%, χ2=10.310, P<0.01), wheezing (8.5% vs 0.0%, χ2=8.114, P<0.01) and expectoration (19.2% vs 7.9%, χ2=10.310, P<0.01) than that of non-asthma group. Besides, patients with cough and/or wheezing in the asthma group had more impact on exercise and sleep (16.1% vs 0, χ2=5.436, P<0.05) and a longer duration over 4 weeks (25.1% vs 3.7%, χ2=6.244, P<0.05). Conclusions: The most common symptoms in children with allergy infected with COVID-19 Omicron variant were fever and cough. Children under 3 years of age had relatively fewer respiratory symptoms while those with asthma or aged 3-6 years were more likely to have cough and wheezing and longer duration of symptoms. The data suggested that the prevention and management of COVID-19 should be strengthened in children with allergy.

Guidance on the management of adverse reactions induced by poly(ADP-ribose) polymerase inhibitors / 浙江大学学报·医学版

The common adverse reactions caused by poly (ADP-ribose) polymerase (PARP) inhibitors include hematological toxicity, gastrointestinal toxicity and fatigue. The main prevention and treatment of hematological toxicity include: regular blood tests, referral to hematology department when routine treatment is ineffective, and being alert of myelodysplastic syndrome/acute myeloid leukemia. The key points to deal with gastrointestinal toxicity include: taking medicine at the right time, light diet, appropriate amount of drinking water, timely symptomatic treatment, prevention of expected nausea and vomiting, and so on. For fatigue, full assessment should be completed before treatment because the causes of fatigue are various; the management includes massage therapy, psychosocial interventions and drugs such as methylphenidate and Panax quinquefolius according to the severity. In addition, niraparib and fluzoparib can cause hypertension, hypertensive crisis and palpitation. Blood pressure and heart rate monitoring, timely symptomatic treatment, and multidisciplinary consultation should be taken if necessary. When cough and dyspnea occur, high resolution CT and bronchoscopy should be performed to exclude pneumonia. If necessary, PARP inhibitors should be stopped, and glucocorticoid and antimicrobial therapy should be given. Finally, more attention should be paid to drug interaction management, patient self-management and regular monitoring to minimize the risk and harm of adverse reactions of PARP inhibitors.

Tiaoshen acupuncture for primary insomnia: a pilot randomized controlled trial / 中国针灸

OBJECTIVE@#To observe the effects of Tiaoshen (regulating the spirit) acupuncture on cognitive function and sleep quality in patients with primary insomnia (PI).@*METHODS@#Sixty patients with PI were randomly divided into an observation group (30 cases, 2 cases dropped off) and a control group (30 cases, 2 cases dropped off, 1 case was excluded). The patients in the observation group were treated with acupuncture at Baihui (GV 20), Shenting (GV 24), Sishencong (EX-HN 1), and bilateral Benshen (GB 13), Shenmen (HT 7), Neiguan (PC 6), Sanyinjiao (SP 6). The patients in the control group were treated with shallow needling at non-effective points. Each treatment was provided for 30 min, once every other day, 3 treatments per week for 4 weeks. The Montreal cognitive assessment (MoCA), digit span test (DST), trail making test (TMT)-A, Pittsburgh sleep quality index (PSQI), and fatigue scale-14 (FS-14) were used to assess cognitive function and sleep quality before and after treatment, as well as in follow-up of 4-week after treatment completion. Correlation analysis was conducted between the differences in PSQI scores and differences in MoCA scores before and after treatment in the observation group.@*RESULTS@#Compared with before treatment, the total score, visuospatial and executive function score and delayed memory score of MoCA as well as DST backward score were increased (P<0.01), while TMT-A time, PSQI and FS-14 scores were significantly reduced (P<0.01) after treatment and in follow-up in the observation group. Compared with before treatment, the PSQI score in the control group was reduced (P<0.01, P<0.05). After treatment and in follow-up, the observation group had significantly higher total score, visuospatial and executive function score, delayed memory score of MoCA, and DST backward score compared to the control group (P<0.05, P<0.01). In the observation group, the TMT-A time was significantly shorter than that in the control group (P<0.05, P<0.01), and the PSQI and FS-14 scores were significantly lower than those in the control group (P<0.01). In the observation group, there was a negative correlation between the difference in PSQI scores (post-treatment minus pre-treatment) and the difference in MoCA scores (post-treatment minus pre-treatment) (r=-0.481, P<0.01). A similar negative correlation was found between the difference in PSQI scores (follow-up minus pre-treatment) and the difference in MoCA scores (follow-up minus pre-treatment) (r=-0.282, P<0.05).@*CONCLUSION@#Tiaoshen acupuncture could improve cognitive function, enhance sleep quality, and alleviate daytime fatigue in patients with PI. The improvement in cognitive function in patients with PI is correlated with the improvement in sleep quality.

Acupuncture at "umbilical four-acupoints" for chronic insomnia and its comorbid symptoms / 中国针灸

OBJECTIVE@#To observe the effects of acupuncture at "umbilical four-acupoints" on chronic insomnia and its comorbid symptoms.@*METHODS@#A total of 120 patients with chronic insomnia were randomly divided into an observation group (60 cases, 8 cases dropped off) and a control group (60 cases, 5 cases dropped off). The patients in the observation group were treated with acupuncture at regular acupoints (Baihui [GV 20] and bilateral Shenmen [HT 7], Neiguan [PC 6], Anmian [Extra]) and "umbilical four-acupoints", while the patients in the control group were treated with acupuncture at regular acupoints. Acupuncture was given once a day, 6 times a week, for a total of 3 weeks in the two groups. The Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI) scores were observed before treatment, after treatment and in follow-up of one month after treatment completion; the Beck anxiety inventory (BAI), Beck depression inventory (BDI), fatigue severity scale (FSS), and Epworth sleepiness scale (ESS) scores were observed before and after treatment; the sleep parameters of polysomnography (PSG), including sleep latency (SL), awake-up time (AT), sleep efficiency (SE) and total sleep time (TST), were observed before and after treatment using polysomnography monitor in the two groups.@*RESULTS@#Compared with those before treatment, the PSQI and ISI scores in both groups were reduced after treatment and in follow-up (P<0.05), and the PSQI and ISI scores in the observation group were lower than those in the control group after treatment and in follow-up (P<0.05). Compared with those before treatment, the BAI, BDI, FSS and ESS scores in both groups were reduced after treatment (P<0.05), and the BAI, BDI, FSS and ESS scores in the observation group were lower than those in the control group after treatment (P<0.05). Compared with those before treatment, the SL and AT in both groups were reduced after treatment (P<0.05), while SE and TST were increased after treatment (P<0.05); after treatment, the SL and AT in the observation group were lower than those in the control group (P<0.05), while SE and TST in the observation group were higher than those in the control group (P<0.05).@*CONCLUSION@#On the basis of regular acupoint selection, acupuncture at "umbilical four-acupoints" could improve sleep quality, alleviate the severity of insomnia, and improve the comorbid symptoms i.e. anxiety, depression, fatigue and lethargy in patients with chronic insomnia.

Comparação da fadiga relacionada ao câncer de pacientes em tratamento com imunoterápicos ou quimioterápicos / Comparison of cancer-related fatigue in patients undergoing treatment with immunotherapeutic or chemotherapeutic drugs

INTRODUÇÃO: A Fadiga Relaciona ao Câncer (FRC) é uma "sensação persistente e subjetiva de cansaço e esgotamento físico, emocional, e/ou cognitivo, relacionado com o câncer ou o tratamento do mesmo, que não é proporcional à atividade recente e que interfere na capacidade funcional". A FRC, que atinge até 80% dos pacientes, é relatada principalmente por pacientes em tratamento quimioterápico. OBJETIVO: Comparar a fadiga relacionada ao câncer de pessoas com tumores sólidos em tratamento com imunoterapia ou quimioterapia. METODOLOGIA: Foi um estudo observacional transversal analítico, em pacientes adultos, de ambos os sexos, com câncer sólido, que no momento da coleta estavam exclusivamente em tratamento com quimioterápicos ou imunoterápicos. Os voluntários foram separados em dois grupos: grupo Imunoterapia e grupo Quimioterapia. Os instrumentos de avaliação foram: questionário de Avaliação Funcional da Terapia de Doenças Crônicas ­ Fadiga (FACIT-F), que avalia a percepção de fadiga da pessoa em tratamento do câncer. A dinamometria com o dinamômetro Jamar® para avaliar força de preensão manual e teste de velocidade da marcha de 4 metros (VM4M) para avaliar a velocidade da marcha. RESULTADOS: Em relação a velocidade da marcha, o grupo imuno apresentou velocidade média de 1,43 m/s e o grupo quimio apresentou velocidade média de 1,41m/s. Esses resultados apresentam que os pacientes avaliados não apresentaram lentidão de marcha e não tem diferença estatística entre os grupos (p=0.43). Em relação à força de preensão manual, observamos que não tem diferença estatística entre os grupos estudados (p=0,13 mão direita e p=0,10 mão esquerda), porém observamos que o grupo Imunoterapia contém valores maiores de média e mediana para a força de preensão palmar em ambas as mãos, permitindo afirmar que nos pacientes estudados em tratamentos com imunoterápicos apresentaram maior força de preensão manual. Em relação ao inventário de fadiga observa-se que, na amostra estudada, a média do escore final comprova que o grupo Imunoterapia tem menor ocorrência de fadiga (p=0.01). CONCLUSÃO: Não houve diferença estatística entre os grupos na velocidade da marcha e na força de preensão manual. No inventário de fadiga o grupo imunoterapia apresentou menor ocorrência de fadiga com diferença significativa.

INTRODUTION: Cancer Relational Fatigue (CRF) is a "persistent and subjective feeling of tiredness and physical, emotional, and/or cognitive exhaustion, related to cancer or its treatment, which is not proportional to recent activity and which interferes in functional capacity". CRF that meets up to 80% of patients is mainly reported by chemotherapy treatment. Patients being treated with immunotherapics report less fatigue. OBJECTIVE: Compare cancer-related fatigue in people with solid tumors undergoing exclusive immmunotherapy or chemotherapy treatments. This was an observational, cross-sectional and analytical study conducted with adult patients of both genders. The volunteers were distributed in two groups, namely, Immunotherapy and Chemotherapy. The assessment instruments were as follows: Functional Assessment Questionnaire of Chronic Illness Therapy ­ Fatigue (FACIT-F), dynamometry with a Jamar® dynamometer to assess hand grip strength and the 4-meter gait speed (4MGS) test. RESULTS: In relation to gait speed, the Immunotherapy group presented a mean speed of 1.43 m/s while the mean speed in the Chemotherapy group was 1.41 m/s. These results indicate that the patients evaluated did not present low gait speed and do not statistically differ between the groups (p=0.43). In relation to hand grip strength, we did not observe any significant difference between the groups under study (p=0.13 right hand and p=0.10 left hand). However, we noticed that the Immunotherapy group has higher mean and median values for hand grip strength in both hands, allowing us to assert that the patients studied in immunotherapy treatments presented greater hand grip strength. In relation to the fatigue inventory, in the sample studied it is observed that the final score mean proves that the Immunotherapy group presents lower occurrence of fatigue (p=0.01). CONCLUSION: There was no statistical difference between the groups in gait speed and handgrip strength. In the fatigue inventory, the immunotherapy group had a lower occurrence of fatigue with a significant difference.

Autoavaliação de sintomas relacionados à voz em indivíduos com câncer de tireoide antes, imediatamente após e no pós-operatório tardio de tireoidectomia / Self-assessment of voice-related symptoms in individuals with thyroid cancer before, immediately after, and in the late postoperative period of thyroidectomy

RESUMO Objetivo Verificar autopercepção de sintomas vocais, de fadiga vocal e relacionados à tireoidectomia em indivíduos com câncer de tireoide, nos momentos pré-operatório, pós-operatório imediato e pós-operatório tardio, e analisar a influência do gênero. Métodos Trata-se de um estudo de intervenção antes e após com 20 indivíduos com câncer de tireoide, média de 46 anos de idade, avaliados em três momentos: pré-cirurgia (M1), imediatamente após cirurgia (M2) e no pós-operatório tardio (M3) da tireoidectomia. Os indivíduos responderam aos instrumentos Escala de Sintomas Vocais, Índice de Fadiga Vocal e Thyroidectomy-Related Voice and Symptom Questionnaire. Os dados foram analisados ​​de forma descritiva e inferencial. Resultados Na autoavaliação de sintomas vocais físicos e orofaringolaríngeos relacionados à tireoidectomia, o M3 apresentou valores estatisticamente menores que o M1 (p=0,006 e p=0,028, respectivamente) e o M2 (p<0,001 e p=0,004, respectivamente). Para os sintomas totais (p=0,001) e vocais (p=0,001) relacionados à tireoidectomia, os valores do M3 foram significativamente menores que os do M2. Na autoavaliação de sintomas vocais dos domínios total e limitação, o M1 (p<0,001; p<0,001) e o M3 (p=0,013; p=0,001) apresentaram valores significativamente menores que o M2. Indivíduos do gênero masculino apresentaram percepção de sintomas de fadiga no domínio fadiga e limitação vocal (p=0,035) e percepção de sintomas relacionados à tireoidectomia nos domínios total (p=0,044) e sintomas vocais (p=0,012) significativamente menores do que os do gênero feminino, independentemente do momento. Conclusão Sintomas vocais físicos e relacionados à tireoidectomia diminuem no pós-operatório tardio; sintomas vocais totais e limitação aumentam no pós-operatório imediato e diminuem no tardio. Mulheres têm maior percepção de fadiga e limitação vocal e de sintomas totais e vocais relacionados à tireoidectomia.

ABSTRACT Purpose To verify the self-perception of symptoms and vocal fatigue related to thyroidectomy in individuals with thyroid cancer in the pre, immediate post and late post-operative moments, and to analyze the influence of gender. Methods Intervention study before and after with 20 individuals, mean age 46 years, evaluated before surgery (M1), immediately after surgery (M2) and in the late postoperative period (M3) of thyroidectomy. Individuals answered the instruments: Voice Symptoms Scale, Vocal Fatigue Index and Thyroidectomy-Related Voice and Symptom Questionnaire. Data were analyzed descriptively and inferentially. Results In self-assessment of vocal symptoms of the total domains and limitation, M1 (p<0.001; p<0.001, respectively) and M3 (p=0.013; p=0.001, respectively) had significantly lower values than the M2. For the physical domain of self-assessment of vocal symptoms, the M3 showed statistically lower values than the M1 (p=0.006) and the M2 (p<0.001) assessments. Depending on the moment, the oropharyngolaryngeal symptoms in M3 had significantly lower values ​​than M2 (p=0.004) and M1 (p=0.028). Male scores were significantly lower than female scores in the self-assessment of fatigue symptoms in the fatigue and vocal limitation domain (p=0.035), regardless of the time of assessment. Conclusion Physical vocal symptoms and thyroidectomy-related symptoms decrease in the late postoperative period; total vocal symptoms and limitation increasing in the immediate postoperative period and decrease in the late postoperative period. Women have a higher perception of vocal fatigue and limitation, and of total and vocal symptoms related to thyroidectomy.