摘要
Non-alcoholic Steatohepatitis [NASH] is a common liver disease characterized by hepatomegaly, elevated serum aminotransferase levels, and a histological picture similar to alcoholic hepatitis in the absence of alcohol consumption sufficient to cause such changes. Most patients with NASH are obese women, and many have diabetes mellitus, hypercholesterolemia, or hypertriglyceridemia, but it also occurs in younger lean, otherwise healthy individuals. Most of the patients are asymptomatic, although some report fatigue, malaise or right upper quadrant discomfort. The most common sign of NASH is hepatomegaly. Laboratory abnormalities include a two to four fold elevation of serum aminotransferase levels; other liver function tests are usually normal. The pathogenesis of NASH is multifactorial. NASH should be considered in the differential diagnosis of patients with persistently elevated liver enzyme levels, particularly obese patients with diabetes and hyperlipidemia. The course of this disease is highly variable, but it may proceed to cirrhosis. Treatment of NASH is unproven, but weight reduction and altered life style are recommended