摘要
Objective To evaluate the perioperative safety of laparoscopic cholecystectomy(LC) in patients with gallstones complicated with end-stage renal disease(ESRD). Methods Clinical data of 41 patients with gallstones accompanying ESRD treated with LC(ESRD Group) between May 1994 and May 2005 were analyzed retrospectively.Another 200 patients without ESRD(non-ESRD Group) receiving LC during the same period were randomly selected for comparison.Results The patients in the ESRD Group were older than those in the non-ESRD Group(49.8?11.9 years vs 44.2?12.3 years;t=2.655,P=0.008).There were significant differences between the ESRD Group and the non-ESRD Group in hemoglobin levels(76.3?11.7 g/L vs 120.1?8.4(g/L)) and platelet count [(141?36)?10~9/L vs(183?51)?10~9/L)] (t=22.905 and 6.226;P
摘要
Objective To investigate the outcome of induction of tumor cell apoptosis with low dosage of 131 I labelled anti carcinoembryonic antigen(CEA) monoclonal antibody C50( 131 I C50) and the therapeutic efficacy of combining radioimmunotherapy(RAIT) with chemotherapy in colorectal cancer xenografts. Methods Human colorectal cancer xenografts with positive CEA expression were established in nude mice with LoVo cell line. 5 fluorouracil(5 FU), 75 ?Ci 131 I C50, and 5 FU, combined with 131 I C50 were given to nude mice through tail vein to treat xenografts on 9th day after implantation of tumor cells. Fifteen days after implantation, each mouse was sacrificed and tumor tissues were stained with HE and terminal deoxynucleotidyl transferase mediated X DUTP nick end labeling technique(TUNEL technique). Apoptosis index(AI) of xenograft cells in each mouse was calculated. Results Under light microscope, no obvious cytolysis or necrosis of tumor cells was seen in all four groups. Apoptosis indexes in blank control group, chemotherapy group, radioimmunothera py(RAIT) group, and RAIT+chemotherapy group were (0.29?0.08)%, (18.68? 2.69 )%,(40.88 ?4.54 )% and (62.33?8.00)%, respectively. There were significant difference of apoptosis indexes between any groups( P
摘要
Objective To investigate the feasibility and effectiveness of laparoscopic splenectomy (LS) in patients with refractory idiopathic thrombocytopenic purpura (ITP) resistant to medical management. Methods Clinical data of 31 cases of refractory ITP (platelet count
摘要
0.05). Conclusions LS,whereas of less traumatic and low morbidity, results in comparable effects as OS for the treatment of ITP.