摘要
During the treatment of non-small cell lung cancer ( NSCLC) , many patients have developed drug resistance due to the use of targeted EGFR inhibitors. The main reasons for drug resistance are EGFR site mutations and bypass activation. Activation of ALK pathway is one of the major types of bypass activation. A recent authoritative study indicates that ALK is closely related to immunotherapy. This article reviews the treatment of ALK in tumors from three aspects: the structure and physiological function of ALK, the small molecule inhibitor of ALK, the biological function of ALK and its related treatment methods for NSCLC, and prospects future directions for better application of ALK in the treatment of NSCLC.
摘要
<p><b>AIM</b>To study the synthesis and antibacterial activity of ciprofloxacin derivatives.</p><p><b>METHODS</b>Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.</p><p><b>CONCLUSION</b>Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.</p>
Subject(s)
Animals , Female , Mice , Anti-Infective Agents , Chemistry , Pharmacology , Ciprofloxacin , Chemistry , Pharmacology , Escherichia coli , Molecular Structure , Nitroimidazoles摘要
<p><b>AIM</b>To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.</p><p><b>METHODS</b>Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.</p><p><b>CONCLUSION</b>Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.</p>