Is There Any Correlation Between Obstructive Sleepapnoeaand Body Mass Index In Hypertensive Subject

To know the any correlation in obstructive sleep apnea and body mass index in hypertensive Subjects. Obstructive sleep apnoea (OSA) is increasingly being recognized as a major health burden with a strong focus on the associated cardiovascular risk. OSA is a considered as secondary hypertension. Its episodes produce surges in systolic and diastolic pressure that keep mean blood pressure levels elevated at night. In many patients, blood pressure remains elevated during the daytime, when breathing is normal. This was a cross-sectional study conducted on 100 hypertensive subjects both male and female to evaluate the correlation between obstructive sleep apnoea and body mass index in hypertensive subjects in Department of Physiology, Department of Pulmonary Medicine and department of Medicine, at Era's Lucknow Medical College & Hospital, Era University, Lucknow. In these 100 subjects there are underweight (n=5) high risk 1 and low risk 4, Normal (n=52) high risk 18 and low risk 34 Overweight (n=33) high risk 19 and low risk 14 and Obese (n=10) high risk 4 and low risk 6. Average BMI in high risk subjects (n=42) is 25.49±3.88 and in low risk subjects (24.14±5.02) with pvalve0.150 (p>0.05). Early identification of BMI and OSA in hypertensive's subject management may reduce the development of cardiovascular risk in hypertensive subjects

Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus.

The present study was conducted to examine the usefulness of anti-C1q antibody as a marker of disease activity in Indian patients with systemic lupus erythematosus (SLE). We standardized the assay for detection of IgG anti-C1q antibody using ELISA. The normal cut-off level was determined by testing 57 healthy, age and sex matched controls to be 53 units/m1 (mean +/- 2 SD). Patients with SEL (97 females and 13 males) were studied and the following parameters were obtained on all: SLE disease activity index (SLEDAI), anti-C1q, anti-ds DNA and C3. Correlations were tested between these parameters using Spearman's rank correlation coefficients. Anti-C1q was found positive in 66 (60%) patients while anti-ds DNA was found in 78 (71%). The positive predictive values of anti-C1q and anti-ds DNA for lupus nephritis were 59 and 61 per cent respectively. The titres of anti-C1q correlated positively with SLEDAI (P < 0.01) and anti-ds DNA (P < 0.01) and negatively with C3 levels (P < 0.001). No significant correlation was observed between anti-C1q positivity and any particular organ involvement. Similarly, no correlation was found between anti-C1q and proliferative lupus nephritis. Anti-C1q was found positive in 5 of 9 patients with moderate SLEDAI scores and negative for anti-ds DNA antibody. It is concluded that anti-C1q antibody can serve as a general marker for lupus activity, supplementing the currently used serum markers.

Bone mineral content in normal and malnourished children.

Bone mineral content (BMC) was determined at the distal radius in 70 children aged 2-14 years; Group I comprising 34 normal healthy children and Group II 36 malnourished children by the method of single photon absorptiometry. The mean value of BMC in Group I was 0.3 +/- 0.04 g/cm in 2-5 year, 0.52 +/- 0.08 g/cm in 6-10 year and 0.77 +/- 0.88 g/cm in 11-14 year age groups. No significant difference in the BMC was seen between boys and girls. An increase of BMC corresponded to growth spurts in 2-5 year and 11-14 year age groups. There was a significant reduction of BMC in Group II and in grade III malnutrition in 2-5 year and 11-14 year age groups as compared to Group I children. The study provides normal BMC data for Indian children and suggests that this can help to detect undemineralization of bones in malnourished children during the growth periods.