摘要
A soluble antigen complex (SAC) derived from the ruptured promastigotes of Leishmania donovani parasites (LD-SAC) was used for complement fixation test (CFT) in leprosy Cases of tuberculoid and borderline tuberculoid leprosy, post-kala azar dermal leishmaniasis (TT, BT, PKDL) and control sera gave negative CFT. Smear-positive cases of borderline (BB, BL) and lepromatous (LL) leprosy and drug-resisting cases of pulmonary tuberculosis gave positive CFT; smear-negative cases of LL leprosy sera also gave positive CFT. Sera of smear-negative inactive LL patients contained only PGL-1 and PDIM antigens for a long time after they become inactive. Therefore, the positive CFT in inactive LL makes us suspect whether PGL-1 is present in LD promastigotes.
Subject(s)
Adult , Animals , Antigens, Bacterial/immunology , Antigens, Protozoan/analysis , Complement Fixation Tests , Cross Reactions , Glycolipids/analysis , Humans , Leishmania donovani/growth & development , Leishmaniasis, Visceral/immunology , Leprosy/diagnosis , Leprosy, Borderline/diagnosis , Leprosy, Lepromatous/diagnosis , Leprosy, Tuberculoid/diagnosis , Male , Middle Aged , Mycobacterium leprae/immunology , Tuberculosis, Multidrug-Resistant/diagnosis摘要
Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.