摘要
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
Subject(s)
Oleanolic Acid , Structure-Activity Relationship , Anti-Inflammatory Agents/pharmacology , Triterpenes , Anti-Bacterial Agents/pharmacology摘要
Objective To explore the treatment effects of low molecular weight heparine (LMWH) on severe acute pancreatitis (SAP). Methods Random analysis were made on the clinical features and therapeutic effect on the control treatment group (CT) in 65 cases and LMWH treatment group (LT) in 77 cases.Results 70(90 9%) cases were cured in LT group,and 48(73 8%) cases were cured in CT group. The incidence of complications in the LT group (28 6%, 22patients 45 times) was significantly lower than that in the CT group (60%,39patients 79 times)(P
摘要
Objective To investigate the effects of low molecular weight heparin (LMWH) on severe acute pancreatitis(SAP). Methods Retrospective analysis was made on the clinical features and therapeutic effect on the routine treatment (RT) group in 48 cases and LMWH treatment(LT) group in 31 cases. Results 28 (90.3%) out of 31 cases were cured while 3 (9.7%) died in LT group. 35(72.9%) out of 48 cases were cured whereas 15 (27.1%) died in RT group. The complications occurring in LT group (32.3%,10 patients 18 times ) was significantly lower than that in the RT group (62.5%,30 patients 59 times)(P