Rapid recovery of diabetes two months after discontinuation of tacrolimus [FK-506] in a single lung transplant patient

Post-transplant diabetes mellitus [PTDM], developing in almost one quarter of renal transplant patients within three years after the procedure, contributes to post-transplant morbidity and mortality by increasing the risk of infection and cardiovascular events. PTDM is considered a variant of diabetes mellitus [DM] type II and results in similar microvascular and macrovascular diabetic complications seen in non-transplant patients. In this article, we present a case of single lung transplant patient who developed PTDM with a severe DKA as the first manifestation of the disease. PTDM resolved rapidly after discontinuing tacrolimus

Prevalence and severity of asthma symptoms in students of Tehran and Rasht: phase III ISAAC study

This study is a part of the third phase of the "International Study of Asthma and Allergy in Childhood" [ISAAC] aiming to study the prevalence and severity of asthma symptoms among children of Rasht and Tehran. Materials and This analytical cross-sectional study assessed Rasht and Tehran students in two age groups [6-7 and 13-14 years] during 2001-2002. After performing statistical analysis, prevalence of asthma symptoms was compared between the students form the two cities and was evaluated in both sexes and age groups by using the Chi-square test. Result: A total of 12,214 students from both Rasht and Tehran participated in this study. History of wheezing and asthma were significantly higher among Rasht students. Prevalence of wheezing, speech limitation due to wheezing, wheezing during exercise and dry nocturnal cough were higher among 13-14 year olds in both cities. History of wheezing and exercise wheezing were higher in 6-7 year-old girls living in Tehran. However, prevalence of the aforementioned symptoms and prevalence of asthma were higher in total boys residing in Rasht. Also, prevalence of asthma, wheezing during exercise and dry nocturnal cough were higher in 13-14 year old boys in Rasht. No significant difference was found in this regard between Tehran girls and boys in this age group. Prevalence of asthma and some of its symptoms was significantly higher among Rasht students compared to those residing in Tehran

Achalasia as a potential predisposing factor for lung allograft rejection

Microaspiration secondary to gastroesophageal reflux has been postulated to be a predisposing factor for development of bronchiolitis obliterans syndrome after lung transplantation. Esophageal manometry and ambulatory pH monitoring have been suggested as a screening test in patients with end-stage lung disease. We report a single lung transplant patient who developed allograft rejection presumed to be due to underlying achalasia as the patient's clinical status and lung function improved markedly following the treatment of achalasia