摘要
OBJECTIVE@#This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease (CVD) burden from 1990 to 2019.@*METHODS@#Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study 2019. Deaths and disability-adjusted life years (DALYs) were used to quantify heat-induced CVD burden. We calculated the age-standardized mortality rate (ASMR) and DALY rate (ASDR) per 100,000 population to compare this burden across regions. Generalized linear models were applied to evaluate estimated annual percentage changes (EAPC) for temporal trends from 1990 to 2019. The correlation between the socio-demographic index (SDI) and age-standardized rate was measured using the Spearman rank test.@*RESULTS@#Heat-induced CVD caused approximately 90 thousand deaths worldwide in 2019. Global ASMR and ASDR of heat-related CVD in 2019 were 1.17 [95% confidence interval ( CI): 0.13-1.98] and 25.59 (95% CI: 2.07-44.17) per 100,000 population, respectively. The burden was significantly increased in middle and low-SDI regions and slightly decreased in high-SDI regions from 1990 to 2019. ASMR showed an upward trend, with the most considerable increase in low-latitude countries. We observed a negative correlation between SDI and EAPC in ASMR ( r s = -0.57, P < 0.01) and ASDR ( r s = -0.59, P < 0.01) among 204 countries.@*CONCLUSION@#Heat-attributable CVD burden substantially increased in most developing countries and tropical regions.
Subject(s)
Humans , Quality-Adjusted Life Years , Cardiovascular Diseases/etiology , Hot Temperature , Temperature , Global Health , Global Burden of Disease摘要
Objective@#To screen the differential expression profile of circular RNA (circRNA) in pancreatic cancer and analyze its potential function.@*Methods@#Four pairs of pancreatic cancer tissues and corresponding adjacent pancreatic tissues were selected for high⁃throughput sequencing , and the differentially expressed circRNA was screened according to fold change > 2 and P < 0. 05. qRT⁃PCR was used to detect the expression of 5 randomly selected differentially expressed circRNA in 20 pairs of pancreatic cancer tissue samples. GO and KEGG enrichment analysis of differentially expressed circRNA was performed , and the top 50 circRNA⁃microRNA interaction network was constructed. The relationship between hsa_circ_0046523 and the clinicopathological features of pancreatic cancer was further analyzed , and the effects of hsa_circ_0046523 on the proliferation , migration and invasion of pancreatic cancer cells were observed by functional experiments.@*Results@#A total of 17 182 circRNA were predicted by high⁃throughput sequencing , of which 302 circRNA were differentially expressed including 137 circRNA were upregulated and 165 circRNA were downregulated in pancreatic cancer tissues. The qRT⁃PCR results showed that the expression levels of hsa_circ_0046523 , hsa_circ_0004220 and hsa_circ_0000690 in pancreatic cancer tis⁃sues were significantly upregulated (P<0.05)，while the expression levels of hsa_ ir_0008676 and hisa _ circ_0004416 were significantly downregulated (P<0.05）.which was consistent with the sequencing results.GO analysis indicated that differentially expressed circRNA were mainly involved in substrate-dependent cell migration, protein kinase complex and cytoskeletal protein bindinig.KEGG pathway enrichment analysis showed that differentially expressed circRNA were mainly involved in protein digestion and absorption , ABC transporters , central carbon metabolism in cancer,and glycineserine and threonine metabolism pathways.The expression level of hsa_ circ_0046523 was closely correlated with tumor differentiation (P=0.002),T stage (P=0.006),lymph node metastasis (P=0.011) and TNM stage (P=0.001).Compared with HPDE6-C7 cells the expression of hsa_circ_0046523 significantly inc increased in pancreatic cancer SW1990, Mia PaCa-2BxPC-3 and Capan-2 ceIls (P<0.05). hsa_circ_ 0046523 knockdown significantly inhibited the proliferation, migration and invasion of pancreatic cancer Mia PaCa⁃2 BxPC⁃3 cells (P < 0. 05) . @*Conclusion@#There are characteristic differentially expressed circRNAs in pancreatic cancer tissues , and these differentially expressed circRNAs may be involved in the occurrence and development of pancreatic cancer.
摘要
@#ObjectiveTo observe the combined effect and safety of Sodium Ozagrel and Low Molecular Heparin in the treatment of progressive cerebral infraction.Methods80 patients with progressive cerebral infraction were divided into experiment group and control group with 40 patients in each group. Sodium Ozagrel and Clexane both were used in the experimental group, but only Sodium Ozagrel was used in the control group. Platelet packing fraction and 4 items of blood clotting were examined before and 14 d after treatment. Neurofunctional defect was evaluated at the same time in the 2 groups.ResultsPlatelet packing fractions were significantly different when examined before treatment and 14 d after treatment both in 2 groups (P<0.05), but no difference between the 2 groups. The value of APTT 14 d after treatment in the experimental group was significantly increased (P<0.05), while this was not observed in the control group. Total effective power in experimental group was 89.7%, which was much higher than that in control group (77.5%). Neurofunctional defect evaluation in experimental group was significantly improved after treatment(P<0.05) compared with that in control. ConclusionSodium Ozagrel combined with Clexane is more effective on progressive cerebral infraction.
摘要
In early 2004, following an epidemic of avian influenza A/H5N1 in human, an outbreak of influenza A/H3 occurred in 5 communes at Hung Yen province with 887 cases and no deaths. This outbreak developed quickly but only in medium geographical range (inter-commune). Most cases are of school-age (from 5 to 19 years old) which comprise over 85% of the total number and focus mainly in primary and secondary schools. Owing to discovered early the outbreak, consisted of determinate the reasons and response to outbreak quickly and strongly and applied routinely to prevention the spread through the respiratory, and it also the good lesson to the prevention of outbreak
Subject(s)
Disease Outbreaks , Influenza, Human , Epidemiology摘要
Study on 943 patients with syndrome of exudate urethrovaginal, conjunctiva pus at National of Dermatology and venerology Hospital. Isolated 135 types of gonococci (14,31% positive). Using transplant and isolate bacterium techique on blood agar for antibiotic draft. Find out resistant to antibiotic rate of gonococci in Hanoi quite high in most of tested antibiotics. Penicillin was most of resistanced antibiotic 75,55, tetracyclin was 20,74%. In Ha noi occurred types of multi resistance gonococci with 2 antibiotic and 3 antibiotic. Not find any gonococci which resistant to spectinomycin and ceftriaxon in Hanoi
Subject(s)
Epidemiology , Neisseria gonorrhoeae , Diagnosis摘要
50 patients with the odontopathy and odontic advantages of technique of the three dimensional obturation/warm vertical condensation of gutta- percha included easy implementation, close obturation of the accessory root canals and high rate of healing the lesion of endodontic origin and limitations included no application for the odontic pedicle that have not been closed.