摘要
BACKGROUND@#To enhance articular cartilage healing, microfractures (Mfx) and bone marrow aspirate concentrate (BMAC) are commonly used, and some form of scaffold is often used together to increase its efficacy. Herein, we compared the efficacy of atelocollagen scaffold to that of collagen scaffold when used with Mfx or BMAC on osteochondral defect of animal. @*METHODS@#This experiment was designed in two stages, and therapeutic effects of Mfx and BMAC were respectively evaluated when used with atelocollagen or collagen scaffold. Femoral condyle defects were artificially created in male New Zealand White rabbits, and in each stage, 12 rabbits were randomly allocated into three treatment groups: test group with additional atelocollagen scaffold, the positive control group with collagen scaffold, and the negative control group.Then, for 12 weeks, macroscopic and histological evaluations were performed. @*RESULTS@#At 12 weeks, defects in the test group were fully regenerated with normal cartilage-like tissue, and were well integrated with the surrounding cartilage at both stages experiment, whereas defects in the control groups were not fully filled with regenerated tissue, and the tissue appeared as fibrous tissue. Histologically, the regenerated tissue in the test group showed a statistically significant improvement compared to the positive and negative control groups, achieving a similar structure as normal articular cartilage. @*CONCLUSION@#The results showed that implantation of the atelocollagen scaffold enhanced cartilage regeneration following osteochondral defects in rabbits. This suggests that the atelocollagen scaffold can be used with Mfx or BMAC for effective regeneration of osteochondral defects.
摘要
Purpose@#To report a case of secondary Descemet membrane endothelial keratoplasty (DMEK) for graft failure after primary DMEK.Case summary: A 47-year-old female underwent primary DMEK in her left eye with a diagnosis of Fuchs’ endothelial dystrophy. At 6 weeks later, corneal stromal edema with epithelial and subepithelial bullae was first observed. From that point on, the condition of the cornea and the visual acuity continued to degrade. After 7 months, a second DMEK procedure (i.e., a repeat DMEK) for graft failure was performed successfully without any complications. Since the second procedure, the cornea has been clear, and the best-corrected visual acuity has remained at 0.6 for 8 months. @*Conclusions@#To manage graft failure after primary DMEK, we performed a second DMEK procedure. The removal of the previous graft was easy, and there were no complications. Thus, repeat DMEK may be a feasible procedure.
摘要
Purpose@#To report a case of secondary Descemet membrane endothelial keratoplasty (DMEK) for graft failure after primary DMEK.Case summary: A 47-year-old female underwent primary DMEK in her left eye with a diagnosis of Fuchs’ endothelial dystrophy. At 6 weeks later, corneal stromal edema with epithelial and subepithelial bullae was first observed. From that point on, the condition of the cornea and the visual acuity continued to degrade. After 7 months, a second DMEK procedure (i.e., a repeat DMEK) for graft failure was performed successfully without any complications. Since the second procedure, the cornea has been clear, and the best-corrected visual acuity has remained at 0.6 for 8 months. @*Conclusions@#To manage graft failure after primary DMEK, we performed a second DMEK procedure. The removal of the previous graft was easy, and there were no complications. Thus, repeat DMEK may be a feasible procedure.
摘要
PURPOSE: To determine the through-focus optical bench test performance of monofocal, bifocal, and extended depth-of-focus intraocular lenses (IOLs), and to measure their defocus curves.METHODS: A model eye was placed on an optical bench to test three different IOLs (TECNIS ZXR00, ZMB00, and ZCB00; Abbott Medical Optics, Santa Ana, CA, USA). The focus was changed by inserting trial lenses from +1.00 diopters to −4.00 diopters, in increments of +0.25 diopters. The 1951 United States Air Force Resolution chart was used to determine the quality of the images. The degree of similarity with reference images was given by the cross-correlation coefficient, and defocus curves were drawn and compared.RESULTS: Bifocal IOLs showed lower image quality with the addition of minus diopter trial lenses, but showed good image quality at near distance. Bifocal IOLs also showed a ‘double peak’ in their defocus curve. Monofocal IOLs showed a lower image quality and cross-correlation coefficient with addition of lower-diopter trial lenses. The extended depth of focus IOLs showed a single peak in their defocus curve, but had a wider range of diopters and better image quality than monofocal IOLs.CONCLUSIONS: Bifocal IOLs showed a double peak defocus curve, and extended depth of focus IOLs showed a wider diopter range and better image quality than monofocal IOLs.
Subject(s)
Lenses, Intraocular , United States摘要
Purpose@#We report a case of secondary Descemet membrane endothelial keratoplasty (DMEK) to treat graft failure after Descemet stripping endothelial keratoplasty (DSEK).Case summary: A 66-year-old female underwent DSEK of her right eye to treat pseudophakic bullous keratopathy that developed after cataract surgery and intraocular lens exchange. After 5 years, she complained of decreased vision; graft failure was observed. Secondary DMEK was performed; no additional air injection was needed. The corrected visual acuity was 0.2, 3 months after surgery, and the cornea became clear. @*Conclusions@#Visual recovery can be achieved by performing secondary DMEK after primary DSEK graft failure.
摘要
Purpose@#We report a case of secondary Descemet membrane endothelial keratoplasty (DMEK) to treat graft failure after Descemet stripping endothelial keratoplasty (DSEK).Case summary: A 66-year-old female underwent DSEK of her right eye to treat pseudophakic bullous keratopathy that developed after cataract surgery and intraocular lens exchange. After 5 years, she complained of decreased vision; graft failure was observed. Secondary DMEK was performed; no additional air injection was needed. The corrected visual acuity was 0.2, 3 months after surgery, and the cornea became clear. @*Conclusions@#Visual recovery can be achieved by performing secondary DMEK after primary DSEK graft failure.
摘要
Purpose@#To compare optical coherence tomography (OCT) and histological findings of Meibomian glands in rats. Based onthese results, the histological findings of the structures seen using OCT were clarified. @*Methods@#En bloc excision was performed on the upper and lower eyelids in two rats. The axis of the Meibomian gland was verticallyscanned with three-dimensional (3D) OCT and reconstructed into 3D images. The samples were fixed in 10% formalinagain and stained with hematoxylin and eosin. The findings of the OCT and histological examinations were then compared to determinethe histological characteristics of the structures observed in the OCT. @*Results@#The surface of the acinus was well-delineated in the Meibomian glands of rats using OCT. However, no deep acini wereobserved in the central ducts. @*Conclusions@#The structure of Meibomian glands imaged by OCT in rats was limited to the surface of the acinus. The structureof the reconstructed Meibomian gland ex vivo was similar to that of the human Meibomian gland. The possibility of developing anin vivo meibography system was therefore confirmed in animals.
摘要
PURPOSE: To compare the clinical characteristics and prognosis of Fuchs dystrophy patients according to COL8A2 gene mutation status. METHODS: Eighty-one patients (162 eyes) initially diagnosed with Fuchs dystrophy from 1996 to 2015 were divided into two groups according to COL8A2 gene mutation status. Retrospective analysis was performed comparing gender, age at diagnosis, presence of family history, diabetes mellitus, symptoms of blurred vision in the morning, changes in central corneal thickness and endothelial cell density with time, need for corneal transplantation, and pre-operative corneal status in the two groups. RESULTS: Of the 81 patients, 12 were shown to harbor a COL8A2 gene mutation. Individuals with mutation were significantly associated with presence of family history, diabetes mellitus, and blurred vision in the morning (p = 0.021, p = 0.024, p = 0.044, respectively). They also had significantly thicker central cornea and lower endothelial cell density at the time of diagnosis (p = 0.020, p = 0.005, respectively). The differences in central corneal thickness and endothelial cell density between the two eyes in one patient were significantly smaller in patients with gene mutation (p = 0.043, p = 0.022, respectively). Over a 5-year follow-up period, 60.0% of eyes in patients with gene mutation and 19.2% of eyes in patients without gene mutation underwent corneal transplantation, a significant difference between the two groups (p = 0.014). CONCLUSIONS: By testing for COL8A2 gene mutation, early binocular disease progression and the possible need for corneal transplantation in the future can be predicted among patients diagnosed with Fuchs dystrophy.
Subject(s)
Humans , Cornea , Corneal Transplantation , Diabetes Mellitus , Diagnosis , Disease Progression , Endothelial Cells , Follow-Up Studies , Fuchs' Endothelial Dystrophy , Prognosis , Retrospective Studies , Telescopes摘要
Inadequate pain management after total knee arthroplasty (TKA) impedes recovery, increases the risk of postoperative complications, and results in patient dissatisfaction. Although the preemptive use of multimodal measures is currently considered the principle of pain management after TKA, no gold standard pain management protocol has been established. Peripheral nerve blocks have been used as part of a contemporary multimodal approach to pain control after TKA. Femoral nerve block (FNB) has excellent postoperative analgesia and is now a commonly used analgesic modality for TKA pain control. However, FNB leads to quadriceps muscle weakness, which impairs early mobilization and increases the risk of postoperative falls. In this context, emerging evidence suggests that adductor canal block (ACB) facilitates postoperative rehabilitation compared with FNB because it primarily provides a sensory nerve block with sparing of quadriceps strength. However, whether ACB is more appropriate for contemporary pain management after TKA remains controversial. The objective of this study was to review and summarize recent studies regarding practical issues for ACB and comparisons of analgesic efficacy and functional recovery between ACB and FNB in patients who have undergone TKA.
Subject(s)
Humans , Accidental Falls , Analgesia , Arthroplasty , Arthroplasty, Replacement, Knee , Early Ambulation , Femoral Nerve , Knee , Nerve Block , Pain Management , Peripheral Nerves , Postoperative Complications , Quadriceps Muscle , Rehabilitation摘要
PURPOSE: To compare the effectiveness of toric intraocular lens (IOL) implantation and monofocal IOL implantation with a limbal relaxing incision (LRI) for correcting astigmatism in the Korean population. METHODS: The medical records of 79 patients (100 eyes) with corneal astigmatism over 1.25 diopters (D) who underwent toric IOL implantation (toric group; 54 eyes), monofocal IOL implantation with a concurrent LRI (LRI group; 24 eyes), or monofocal IOL implantation without correcting astigmatism (control group; 22 eyes), were retrospectively reviewed. For subgroup analyses, the three groups were subdivided according to preoperative astigmatic severity under 2.5 D. Visual, refractive, and keratometric outcomes were compared 2 and 6 months postoperatively. RESULTS: The uncorrected distance visual acuity was at least 20/25 (0.1 logMAR) in 64.8%, 41.7%, and 27.3% of the toric, LRI, and control group eyes, respectively at 2 months after surgery. The toric group had the greatest refractive cylindrical error change (toric group, −2.48 ± 1.84 D to −0.98 ± 0.92 D; LRI group, −2.02 ± 1.03 D to −1.65 ± 0.86 D; control group, −1.69 ± 0.88 D to −1.49 ± 0.60 D; p < 0.001) and the LRI group showed the greatest mean corneal cylindrical error change (toric group, 2.40 ± 1.33 D to 2.23 ± 1.42 D; LRI group, 1.86 ± 0.44 D to 1.29 ± 0.55 D; control group, 1.60 ± 0.39 D to 1.35 ± 0.60 D; p = 0.025). The 85 eyes with moderate corneal astigmatism (between 1.25 D and 2.5 D) were under evaluation. The toric group showed the highest mean refractive cylindrical change (0.97 ± 0.66 D; p < 0.001), followed by the LRI group (0.53 ± 0.87 D; p = 0.046). CONCLUSIONS: Both surgical techniques significantly reduced astigmatism and had comparable visual outcomes. Toric IOL implantation was more reliable for correcting astigmatism than monofocal IOL implantation with a concurrent LRI regardless of the preoperative astigmatic severity. Both procedures were effective in reducing astigmatism in eyes with moderate corneal astigmatism.
Subject(s)
Humans , Astigmatism , Lens Implantation, Intraocular , Lenses, Intraocular , Medical Records , Retrospective Studies , Visual Acuity摘要
PURPOSE: To compare the long-term prognosis of laser in situ keratomileusis (LASIK) and surface ablation in moderate to high myopia. METHODS: A retrospective study including 87 eyes of 44 myopic patients treated with LASIK or surface ablation from 1995 to 2005 was performed. Follow-up visits were performed at 3 months, 1 year, 5 years, and 8 years. All treated eyes were divided into 2 groups according to preoperative spherical equivalent (SE)- moderate myopia (<-6.0 diopters [D]) and high myopia (≥-6.0 D). The main outcome measures were postoperative uncorrected visual acuity (UCVA), best corrected visual acuity, SE, mean keratometry, safety index, efficacy index, predictability, and complications. RESULTS: Mean SE was -7.05 ± 2.49 D in the LASIK group and -5.25 ± 1.23 D in the surface ablation group. The 10-year SE was -1.78 ± 1.22 D in the LASIK group and -1.35 ± 1.09 D in the surface ablation group, and there was no statistical difference between the 2 groups. At 10 years postoperatively, UCVA was log MAR 0.155 ± 0.161 in the LASIK group and log MAR 0.095 ± 0.140 in the surface ablation group. There were no significant differences in postoperative mean SE, safety index, efficacy index, or complications between the LASIK and surface ablation group at 10 years. CONCLUSIONS: This 10-year follow-up study shows that LASIK and surface ablation for moderate to high myopia have no statistical differences in mean SE, safety index, efficacy index, or complications.
Subject(s)
Humans , Follow-Up Studies , Keratomileusis, Laser In Situ , Myopia , Outcome Assessment, Health Care , Prognosis , Retrospective Studies , Visual Acuity摘要
PURPOSE: To investigate the safeness of cataract surgery in older subjects by comparing the outcomes among different age groups. METHODS: The present study included 150 patients (150 eyes) diagnosed with cataracts that visited the hospital from January 2014 to May 2015 and received phacoemulsification and intraocular lens implantation. The subjects were divided into 5 age groups (40-50, 50-60, 60-70, 70-80 and 80-90). Among the study subjects, 30 patients from each age group were measured for best corrected visual acuity (BCVA), and endothelial cell density (ECD) 2 months after surgery. Intraoperative ultrasound time, cumulative dissipated energy (CDE) and volume of balanced salt solution were also compared among the subjects. RESULTS: The nuclear sclerosis of cataracts before surgery was significantly lower in the 40-50 (2.85 ± 1.05), 50-60 (3.20 ± 0.81), and 60-70 age groups (3.39 ± 0.67) than the 70-80 (4.23 ± 0.68) and 80-90 age groups (4.47 ± 0.51). The CDE during surgery was significantly lower in the 40-50 (10.10 ± 3.20), 50-60 (11.20 ± 3.20) and 60-70 age groups (12.40 ± 3.50) than in the 70-80 (15.10 ± 3.80) and 80-90 age groups (16.70 ± 3.90; p 0.05). The reduction (%) of ECD 2 months after surgery was significantly lower in the 40-50 (17.94 ± 13.50), 50-60 (17.46 ± 9.08) and 60-70 age groups (19.12 ± 16.01) than in the 70-80 (26.36 ± 10.82) and 80-90 age groups (31.80 ± 16.86; p < 0.05). CONCLUSIONS: After cataract surgery, BCVA was not significantly different among the age groups. These findings indicate that cataract surgery using phacoemulsification in older patients is recommended and a viable option since it is relatively safe and provides excellent BCVA effects.
Subject(s)
Humans , Cataract , Endothelial Cells , Lens Implantation, Intraocular , Phacoemulsification , Sclerosis , Ultrasonography , Visual Acuity摘要
PURPOSE: To investigate the safeness of cataract surgery in older subjects by comparing the outcomes among different age groups. METHODS: The present study included 150 patients (150 eyes) diagnosed with cataracts that visited the hospital from January 2014 to May 2015 and received phacoemulsification and intraocular lens implantation. The subjects were divided into 5 age groups (40-50, 50-60, 60-70, 70-80 and 80-90). Among the study subjects, 30 patients from each age group were measured for best corrected visual acuity (BCVA), and endothelial cell density (ECD) 2 months after surgery. Intraoperative ultrasound time, cumulative dissipated energy (CDE) and volume of balanced salt solution were also compared among the subjects. RESULTS: The nuclear sclerosis of cataracts before surgery was significantly lower in the 40-50 (2.85 ± 1.05), 50-60 (3.20 ± 0.81), and 60-70 age groups (3.39 ± 0.67) than the 70-80 (4.23 ± 0.68) and 80-90 age groups (4.47 ± 0.51). The CDE during surgery was significantly lower in the 40-50 (10.10 ± 3.20), 50-60 (11.20 ± 3.20) and 60-70 age groups (12.40 ± 3.50) than in the 70-80 (15.10 ± 3.80) and 80-90 age groups (16.70 ± 3.90; p 0.05). The reduction (%) of ECD 2 months after surgery was significantly lower in the 40-50 (17.94 ± 13.50), 50-60 (17.46 ± 9.08) and 60-70 age groups (19.12 ± 16.01) than in the 70-80 (26.36 ± 10.82) and 80-90 age groups (31.80 ± 16.86; p < 0.05). CONCLUSIONS: After cataract surgery, BCVA was not significantly different among the age groups. These findings indicate that cataract surgery using phacoemulsification in older patients is recommended and a viable option since it is relatively safe and provides excellent BCVA effects.
Subject(s)
Humans , Cataract , Endothelial Cells , Lens Implantation, Intraocular , Phacoemulsification , Sclerosis , Ultrasonography , Visual Acuity摘要
PURPOSE: To report a case of cytomegalovirus (CMV) corneal endotheliitis following penetrating keratoplasty. CASE SUMMARY: A 45-year-old male with a history of re-penetrating keratoplasty due to corneal opacity and graft failure after previous penetrating keratoplasty of his right eye in April 2014, visited our clinic for intermittent injection of the right eye for several weeks (7 months postoperative). Corneal edema, diffuse keratic pigmentation and anterior chamber reaction with decreased endothelial cell density were observed in his right eye using the slit lamp examination. Seven months after keratoplasty, corneal graft rejection were determined but clinical findings showed features of CMV-related corneal endotheliitis. Under the impression of CMV corneal endotheliitis, diagnostic paracentesis was performed for CMV real time polymerase chain reaction (RT-PCR). Additionally, the patient was admitted for intravenous ganciclovir and topical ganciclovir therapy. The next day, the RT-PCR results confirmed CMV infection. After 2 weeks of intravenous ganciclovir treatment, the patient was discharged and prescribed oral ganciclovir for 1 month. A month later, the coin-shaped corneal lesion nearly disappeared. There was no evidence of complication or recurrence. CONCLUSIONS: CMV corneal endotheliitis typically presents with coin-shaped keratic pigmentation and can be confirmed with RT-PCR using aqueous humor collected from the anterior chamber. Due to the long period of systemic and topical steroid therapy, the risk of viral endotheliitis is relatively high in patients with a history of penetrating keratoplasty. Corneal graft rejection is similar to corneal endotheliitis in symptoms and clinical features such as ciliary injection, decreased visual acuity, corneal edema or anterior chamber reaction. In patients after penetrating keratoplasty, CMV RT-PCR should be considered if the clinical features suggest viral endotheliitis.
Subject(s)
Humans , Male , Middle Aged , Anterior Chamber , Aqueous Humor , Corneal Edema , Corneal Opacity , Corneal Transplantation , Cytomegalovirus , Endothelial Cells , Ganciclovir , Graft Rejection , Keratoplasty, Penetrating , Paracentesis , Pigmentation , Real-Time Polymerase Chain Reaction , Recurrence , Slit Lamp , Transplants , Visual Acuity摘要
PURPOSE: To report four cases of split cornea transplantation involving separate Descemet membrane keratoplasty and Deep anterior lamella keratoplasty from a single cornea. CASE SUMMARY: Four donor corneas were separated into the endothelium and other layers. The endothelial layers were transplanted into 4 pseudophakic bullous keratopathy patients, and the other layers were stored in corneal storage media. Deep anterior lamella keratoplasties were performed with the stored corneas in 2 lipid keratopathy and 2 keratoconus patients. Postoperatively, all grafted corneas were stable. CONCLUSIONS: The authors report the first 4 cases of split cornea transplantation in Korea, which is experiencing a shortage of donated corneas. Split cornea transplantation will be of benefit to a large number of patients by separating a single cornea into separate layers to be implanted into two patients.
Subject(s)
Humans , Cornea , Corneal Transplantation , Descemet Membrane , Endothelium , Keratoconus , Korea , Tissue Donors , Transplants摘要
PURPOSE: The purpose of this study was to evaluate minimum 2-year follow-up results of total knee arthroplasty (TKA) performed using a new high-flexion prosthesis design (LOSPA). MATERIALS AND METHODS: The 2- to 4-year results of 191 consecutive TKAs (177 patients) with the LOSPA posterior-stabilized prosthesis were evaluated. The patients were assessed clinically and radiographically using the Knee Society scoring system (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). RESULTS: The mean range of motion (ROM) increased significantly from 117.4degrees (range, 75degrees to 140degrees) preoperatively to 126.7degrees (range, 80degrees to 144degrees) postoperatively (p<0.001). The mean KSS and WOMAC scores improved significantly from 121.4 (range, 42 to 185) and 56.1 (range, 23 to 88) preoperatively to 174.0 (range, 130 to 200) and 16.4 (range, 0 to 85) postoperatively, respectively (both, p<0.001). One knee required revision for deep infection. No knee had aseptic loosening or osteolysis. Radiolucent lines were noted in 15 knees (7.9%). CONCLUSIONS: The new high-flexion total knee prosthesis resulted in no early aseptic loosening of the component and improved postoperative ROM comparable to other high-flexion TKA prostheses at 2- to 4-year follow-ups.
Subject(s)
Humans , Arthroplasty , Follow-Up Studies , Knee Prosthesis , Knee , Ontario , Osteoarthritis , Osteolysis , Prostheses and Implants , Prosthesis Design , Range of Motion, Articular摘要
This study was undertaken to determine the prevalence and the natural course of venous thromboembolism (VTE) without thromboprophylaxis to ascertain whether routine thromboprophylaxis is necessary following unicompartmental knee arthroplasty (UKA) in Korean patients. The medical records and multidetector row computed tomography (MDCT) imaging of the consecutive 77 UKAs in 70 patients were reviewed. In all patients, MDCTs were undertaken preoperatively and at 1-week after surgery, and VTE symptoms were evaluated. At postoperative 6-months, follow-up MDCTs were undertaken in all patients in whom VTEs were newly detected after surgery. VTE lesions were newly detected in 18 (26%) of the 70 patients. However, none of the patients complained of VTE-related symptoms and MDCT demonstrated that all VTEs were small and involved limited portion without lower leg edema or pleuroparenchymal complication. At the 6-month follow up MDCT, all types of VTEs were shown to be completely resolved, regardless of their location. All of the VTE lesions maintained an asymptomatic status for 6-month after surgery. VTE following UKA in Korean patients who do not receive thromboprophylaxis seems to occur frequently, but all of the VTEs are clinically insignificant and all VTEs are spontaneously regressed. Routine thromboprophylaxis or thrombolytic treatment in Korean patients undergoing UKA may not be necessary.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Arthroplasty, Replacement, Knee , Asian People , Fibrinolytic Agents/therapeutic use , Knee/diagnostic imaging , Postoperative Complications , Republic of Korea , Retrospective Studies , Risk Factors , Tomography, X-Ray Computed , Venous Thromboembolism/diagnostic imaging摘要
PURPOSE: To investigate the clinical features and prevalence of patients with laser iridotomy-induced bullous keratopathy in Korea. METHODS: Using a retrospective study, the patients with laser iridotomy-induced bullous keratopathy who underwent penetrating keratoplasty were selected. We investigated the duration from iridotomy to corneal decompensation, preoperative anterior chamber depth, axial length, keratometry, and survival time of the grafted cornea. The data were compared with the data of patients with pseudophakic bullous keratopathy as controls. RESULTS: Laser iridotomy-induced bullous keratopathy was found in 17 eyes, which represented 2.3% of penetrating keratoplasty cases (727) and 8.5% of bullous keratopathy cases (201), with a mean age of 66.9 years. The laser iridotomy-induced bullous keratopathy group showed a higher female ratio (15 out of 17), shorter mean axial length (22.09 +/- 0.79 mm) and anterior chamber depth (1.91 +/- 0.36 mm) than the control group (15 out of 50, 24.30 +/- 2.54 mm and 3.27 +/- 0.66 mm, respectively) with a statistical significance (p = 0.002, p < 0.001 and p < 0.001, respectively). Mean survival time of the grafted cornea was 39.9 +/- 8.6 months in the group of laser iridotomy-induced bullous keratopathy, which was shorter than the control group (47.8 +/- 3.1 months) without statistical significance (p = 0.47). CONCLUSIONS: In Korea, laser iridotomy-induced bullous keratopathy shows non-negligible prevalence and should be further investigated.
Subject(s)
Female , Humans , Anterior Chamber , Cornea , Keratoplasty, Penetrating , Korea , Prevalence , Retrospective Studies , Survival Rate , Transplants摘要
PURPOSE: To evaluate the clinical efficacy and shortcomings of neodymium-doped yttrium aluminum garnet (Nd-YAG) laser membranotomy in inadvertently retained host membrane. METHODS: Among 742 patients who underwent penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) surgery at Seoul St. Mary's Hospital between January 2007 and May 2013 by a single surgeon, 10 patients had a thin, opaque membrane in the anterior chamber observed under slit lamp examination and both a subjective decrease in visual acuity and decrease i best corrected visual acuity. A single surgeon performed membranotomy using the Nd-YAG laser at 4.9 months after graft surgery. In this study we compared the differences in visual acuity, endothelial cell count and correlations between distance from donor endothelium and retained host membrane and endothelial loss before and after the graft surgery. RESULTS: Patients who had Nd-YAG laser membranotomy performed on the retained host membrane showed significant improvements in visual acuity (p = 0.039). Donor endothelial cell count was significantly reduced 1 month after Nd-YAG laser. The average distance between donor endothelium and retained host membrane was 712.0 +/- 217.5 microm. The distance and the decreased donor endothelial cell count were not statistically correlated (R2 = 0.39, p = 0.072). There were no significant complications after the laser membranotomy. CONCLUSIONS: Inadvertently retained host membrane forms close to the donor endothelium as identified on optical coherence tomography (OCT) images. Nd-YAG laser membranotomy significantly affected clear vision but endothelial cell count loss was also observed.
Subject(s)
Humans , Aluminum , Anterior Chamber , Corneal Transplantation , Endothelial Cells , Endothelium , Keratoplasty, Penetrating , Lasers, Solid-State , Membranes , Seoul , Tissue Donors , Tomography, Optical Coherence , Transplants , Visual Acuity , Yttrium摘要
PURPOSE: To seek for mechanisms to prevent fixed dilated pupil including Urrets-Zavalia syndrome after intraocular surgery by analyzing and classifying the causes of such cases. METHODS: Medical records and anterior segment photographic images of patients with fixed dilated pupil who underwent penetrating keratoplasty, lamellar keratoplasty, or cataract surgery were analyzed in a retrospective manner from April, 1984 to February, 2014. RESULTS: Among 15 cases of postoperative fixed dilated pupil, 8 eyes of keratoconus eyes had received penetrating keratoplasty done and 7 eyes with ocular disorders other than keratoconus underwent intraocular surgeries. In cases 1 and case 2, which received penetrating keratoplasty for keratoconus, dilated pupil with regular pupil border, iris atrophy, and secondary glaucoma occurred; these cases were classified as group 1 and diagnosed as Urrets-Zavalia syndrome. Cases from 3 to 8 which also received penetrating keratoplasties due to keratoconus, irregularly dilated pupil, severe iris atrophy, posterior synechiae after moderate to severe inflammation in the anterior chamber, and fibrotic membrane on the anterior capsule occurred; these cases were classified as group 2. Finally, cases 9 to 15, which had mild inflammation, no fibrotic membrane, and regularly fixed dilated pupil after receiving other intraocular surgeries were classified as group 3. CONCLUSIONS: Differences exist between definite Urrets-Zavalia syndrome and postoperative fixed dilated pupil with regards to regularity of pupillary margin, degree of iris atrophy, posterior synechiae, fibrotic membrane, and posterior subcapsular opacity. Therefore, a new classification of fixed dilated pupil after intraocular surgery which addresses these characteristics is required and various trials to prevent the adverse postoperative complications of fixed dilated pupil should be performed. Preventive measures may include careful control of intraocular pressure, restricting atropine use, completely removing of viscoelastics, and minimal air or gas injection.