摘要
Objective To compare the incidence of intracranial and extracranial artery stenosis between patients with different degrees of dysglycemia,and investigate early curative methods of diabetes-related stenosis.Methods One hundred and thirty two consecutive pre-diabetes patients,268 diabetes and 235 healthy controls,collected in our hospital from December 2011 to November 2012,were enrolled; and risk factors,including blood fat,fasting glucose,2-h glucose and fasting insulin,were recruited and analyzed; neck vascular color Doppler and transcranial vascular color Doppler ultrasounds were performed on these patients and compared the incidences of intracranial and extracranial stenoses,single-and multi-branches,and anterior and posterior circulation vascular stenoses among three groups.Results The incidences of intracranial and extracranial stenoses in the control,pre-diabetes and diabetes groups were 5.5％ (13/235),7.6％ (10/132) and 22.4％ (60/268),respectively,with statistical differences (x2=35.738,P=0.000); the incidences of extracranial stenosis,intracranial stenosis,and intracranial and extracranial stenoses in control,pre-diabetes and diabetes groups increased with significant difference (P＜0.05); the incidence of intracranial stenosis of all groups were higher than that of extracranial stenosis.The incidence of multi-branches stenosis in the dysglycemia group were higher than that in the control group with statistical difference (P＜0.05).The incidence of multi-branches stenosis was higher than that of single-branch stenosis in the dysglycemia group.The incidence of anterior circulation stenosis in control,pre-diabetes and diabetes groups increased with significant difference (P＜0.05).Conclusions Dysglycemia related atherosclerotic stenosis maybe stemmed from early stage ofpre-diabetes,and early measurement and administration ofatherosclerotic stenosis should be taken from the early stage.
摘要
Objective To investigate the impacts of body mass index (BMI) and age on in vitro fertilization-embryo transfer (IVF) and intracytoplasmic sperm injection (ICSI) treatment in infertile patients without polycystic ovary syndrome (PCOS). Methods A retrospective study of 1426 patients during Jun. 2001 - Nov. 2009 was carried out. Multiple regression was used to analyze the effects of BMI (low weight: BMI＜18.5 kg/m2, normal weight:BMI 18.5-23.99 kg/m2 and over weight-obesity: BMI≥24 kg/m2) and age (young: 20-34 years old, eld: 35-45 years old) on controlled ovarian stimulation (COH)[including:dose and duration of Gn, E2 level on day of human chorionic gonadotropin (HCG) administration, number of oocytes collected and full-grown follicles ],number of fertilization, cleavage, two-pronucleus, normal embryos and cryopreserved embryos and clinical pregnancy outcome. Results ( 1 ) Gn dose for the patients whose age were 35 and the above,had a positive correlation with age (P＜0.001), 12.70% of the total variation of Gn dose was related to age (standardized partial regression coefficient was 0.343). (2) Estradiol level on day of HCG administration had a negative correlation with BMI in overweight-obesity patients, and so were the patients whose age were 35 and above (P value respectively lower than 0.037 and 0.018). 0.80% of the total variation of estradiol (HCG day) is related to age and overweight-obesity while age took greater proportion (standardized partial regression coefficients were 0.066 and 0.058 respectively). (3)For older patients, age appeared to have negative relationships with duration of Gn and number of oocytes collected, full-grown follicles, fertilization, cleavage, two-pronucleus, normal embryos and cryopreserved embryos (P＜0.05). (4)Compared to young-normal weight patients, the odds ratio of pregnancy in eld-low weight and eld-overweight-obesity patients were 0.482 and 0.529 (P＜0.05)respectively. Conclusion Age, but not the BMI, had significant effects on IVF/ICSI treatment. It seems that factors as losing weight before IVF or ICSI treatment effective in reducing the dose of Gn.