摘要
AIM To investigate the clinical effects of Jingu Xiaotong Powder combined with platelet-rich plasma on patients with knee osteoarthritis.METHODS Ninety-six patients were randomly assigned into control group(48 cases)for 8-week administration of platelet-rich plasma,and observation group(48 cases)for 8-week administration of both Jingu Xiaotong Powder and platelet-rich plasma.The changes in clinical effects,IL-17,SDF-1,TLR4,GSH-Px,NO,ox-LDL,WOMAC scores,TCM syndrome score,AIM2-SF score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased IL-17,SDF-1,TLR4,NO,ox-LDL,WOMAC scores,TCM syndrome score(P<0.05),and increased GSH-Px,AIM2-SF score(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with knee osteoarthritis,Jingu Xiaotong Powder combined with platelet-rich plasma can reduce IL-17,SDF-1,TLR4 levels,inhibit body inflammation,improve oxidative stress indices,alleviate pain,and enhance clinical efficacy and life quality.
摘要
Objective:To observe the clinical efficacy of modified Chushi Juanbitang combined with pedicle vertebrotomy on kyphosis of ankylosing spondylitis due to syndrome of dampness-heat obstruction. Method:The 90 cases were randomly divided into control group and observation group, 45 cases in each group. The patients in control group received pedicle vertebrotomy + <italic>Tripterygium</italic> glycosides, and the patients in observation group received pedicle vertebrotomy + modified Chushi Juanbitang. The treatment course was 6 months in both groups. Their bath ankylosing spondylitis disease activity index (BASDAI), bath ankylosing spondylitis measure index (BASMI), imaging index, traditional Chinese medicine syndromes, serum proinflammatory factor, anti-inflammatory factor, bone metabolism index [bone-specific alkaline phosphatase (BALP), tartrate resistant acid phosphatase isomer-5b (TRACP-5 b), bone morphogenetic protein-2 (BMP-2), osteocalcin (BGP)], ossification related proteins [bone morphogenetic protein-7 (BMP-7), dickkopf-related protein-1 (DKK-1), and tissue inhibitor matrix metalloproteinase-2 (TIMP-2), sclerostin(SOST)] were observed and detected. The clinical efficacy, recurrence rate and safety indexes were followed up for 12 months and compared. Result:The total effective rate was 97.73% (43/44) in the observation group, higher than 80.95% (34/42) in the control group (<italic>χ</italic><sup>2</sup>=5.172, <italic>P</italic><0.05). In the comparison with control group after treatment, the BASDAI, BASMI, imaging index, traditional Chinese medicine syndromes, proinflammatory factors, TRACP-5b, BMP-7 and TIMP-2 were lower in observation group (<italic>P</italic><0.05), and the anti-inflammatory factors, BALP, BMP-2, BGP, DKK-1 and SOST were higher in observation group (<italic>P</italic><0.05). During the follow-up for at least 12 months, the recurrence rate was 4.65% (2/43) in observation group, lower than 26.47% (9/34) in control group (<italic>χ</italic><sup>2</sup>=4.261, <italic>P</italic><0.05). There was no significant difference in the incidence of postoperative complications between the two groups. The incidence of adverse reactions was 2.27% (1/44) in observation group, lower than 38.64% (17/44) in control group (<italic>χ</italic><sup>2</sup>=5.763, <italic>P</italic><0.05). Conclusion:Modified Chushi Juanbitang combined with pedicle vertebrotomy is effective in the treatment of kyphosis of ankylosing spondylitis due to syndrome of dampness-heat obstruction.