摘要
With rapid development of information technology in health field,making use of medical data to establish disease-related early warning models has been applied to many diseases,which can help predict onset,diagnosis and prognosis of diseases.Cardio-and cerebrovascular diseases are main causes of death in the elderly.Establishment of relevant early warning models can help to screen or predict cardio-and cerebrovascular diseases and facilitate timely treatment or intervention.The present article makes a review on research progress on establishment of cardio-and cerebrovascular disease related early warning model,aiming at exploring application direction of early warning mod-el and providing reference for related research.
摘要
The anti-tumor activities and mechanism of Erythrina variegata L. extract were investigated. Firstly, the MTT method was used to evaluate the inhibitory activity of the Erythrina variegata L. extract on proliferation of cancer cell lines. Moreover, in order to determine its anti-tumor effect in vivo, the Lewis lung cancer mice model was established. By comparing the relative tumor proliferation rates, growth curves, inhibition rates of different groups, the anti-tumor effect was evaluated. Furthermore, the anti-tumor mechanism of Erythrina variegata L. extract was studied by using G-quadruplex stability experiment. In the in vitro anti-liver cancer experiment, the Erythrina variegata L. extract has shown obvious anti-tumor effect on various tumor cells. And in the in vivo experiment, it exhibited significant anti-tumor effect. Besides, from the result of G-quadruplex stability experiment, we can see that the quadruplex structure show increasing T(m) values with increasing amounts of Erythrina variegata L. extract.