摘要
Objective: To study the chemical constituents from the roots of Lycium chinense. Methods: The compounds were isolated and purified by silica gel, ODS and Sephadex LH-20 chromatography in addition to preparative-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analysis. Results: Twelve compounds were isolated from the EtOAc fraction of the root of Lycium chinense and identified as grossamide K (1), grossamide (2), dihydrogrossamide (3), cannabisin H (4), 1,2-dihydro-6,8-dimethoxy-7-hydroxy-1-(3,4-dihydroxyphenyl)-N1,N2-bis [2-(4-hydroxyphenyl)ethyl]-2,3-naphthalene dicarboxamide (5), cannabisin D (6), (1,2-trans)-N3-(4-acetamidobutyl)-1-(3,4-dihydroxyphenyl)-7-hydroxy-N2-(4-hydroxyphenethyl)-6,8-dimethoxy- 1,2-dihydronaphthalene-2,3-dicarboxamide (7), cannabisin F (8), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl} phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-acetamidobutyl)acrylamide (9), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxylphenethyl) amino]-3-oxopropyl}phenyl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(4-hydroxyphenethyl)acrylamide (10), (+)-lyoniresinol-3α-O-β-D- glucopyranoside (11), and (−)-lyoniresinol-3α-O-β-D-glucopyranoside (12). Conclusion: Compound 3 is a new natural product. Compounds 1, 2, and 4—8 are isolated from this plant for the first time.
摘要
Objective: To study the chemical constituents in the seeds of Datura metel. Methods: The constituents were isolated and purified by silica gel, ODS, and Sephadex LH-20 column chromatographies as well as HPLC. Their chemical structures were elucidated on the basis of spectral data. Results: The compounds were isolated from the EtOAc fraction of D. metel extract and identified as cannabisin D (1), cannabisin E (2), cis-cannabisin E (3), cannabisin F (4), cannabisin L (5), cannabisin G (6), grossamide K (7), hyoscyamilactol (8), daturaolone (9), N-trans-feruloyl tryptamine (10), and fraxetin (11), respectively. Conclusion: Compounds 2 and 4 are firstly isolated from the plants in Solanaceae, compounds 1, 3, and 5-7 are firstly isolated from the plants in genus Datura L. and compounds 8-11 are isolated from this plant for the first time.