摘要
A 36 year-old man after tests for assessing male infertility was diagnosed with primary infertility, bilateral cryptorchidism, nonobstructive azoospermia and discontinuous splenogonadal fusion. Carcinoma in situ was found in his left testicle, which was intraabdominal and associated with splenogonadal fusion. To our knowledge, this is the fourth case of splenogonadal fusion associated with testicular cancer reported. One should always bear in mind the possibility of this association for the left cryptorchid testicle.
Um homem de 36 anos, depois de ser submetido a exames para avaliação de infertilidade masculina, foi diagnosticado com infertilidade masculina primária, criptorquidia bilateral, azoospermia não obstrutiva e fusão esplenogonadal descontínua. Carcinoma in situ estava presente no testículo esquerdo, que tinha localização intra-abdominal e estava associado à fusão esplenogonadal. Esse é o quarto caso de fusão esplenogonadal associada a câncer testicular, segundo nossa avaliação. Deve-se sempre ter em mente a possibilidade dessa associação em testículos criptorquídicos à esquerda.
Subject(s)
Humans , Male , Adult , Carcinoma in Situ/diagnosis , Cryptorchidism/etiology , Spleen/abnormalities , Testicular Neoplasms/diagnosis , Testis/abnormalities , Atrophy , Azoospermia/etiology , Calcinosis/etiology , Carcinoma in Situ/etiology , Carcinoma in Situ/pathology , Cryptorchidism/embryology , Cryptorchidism/surgery , Disease Susceptibility , Incidental Findings , Magnetic Resonance Imaging , Orchiectomy , Orchiopexy , Spleen/embryology , Testicular Diseases/etiology , Testicular Neoplasms/etiology , Testicular Neoplasms/pathology , Testis/embryology摘要
El bazo es el órgano linfático periférico más grande del organismo y conocer sus aspectos morfológicos cuantitativos es importante para determinar posibles patologías. El objetivo del estudio fue determinar en dos especies: cuye (Cavia porcellus) y rata (Rattus novergicus Sprague Dawley), las características estereológicas del bazo, para obtener patrones de normalidad cuantitativos, los que servirán de base para futuros estudios morfofuncionales. Se utilizaron 5 bazos de cada especie, clínicamente sanos, obtenidos del Bioterio de la Universidad de La Frontera, Temuco, Chile. Los bazos fueron disecados y fijados en formalina tamponada al 10 por ciento y se determinó el volumen de éstos por el método de Scherle. Se obtuvieron 5 trozos por medio de Orientador los que fueron incluidos en paraplast. De cada trozo se obtuvieron 5 cortes histológicos de 3 micrones m de grosor y separados 200 micrones m entre sí, los cuales fueron teñidos con H-E. El porcentaje de pulpa roja, pulpa blanca y zona marginal en el bazo del cuye fue: 65,14 por ciento, 21,96 por ciento y 12,67 por ciento, respectivamente, y en la rata 53,9 por ciento de pulpa roja, 25,75 por ciento pulpa blanca y 15,87 por ciento de zona marginal. El número total de folículos fue 8,33 x 10² y 5,73x 10² para el cuye y la rata, respectivamente. Los resultados concuerdan con los obtenidos por otros autores, pudiéndose señalar un patrón cuantitativo del porcentaje de los compartimentos esplénicos de normalidad, que se podría considerar para futuros estudios morfo-funcionales.
The spleen is the largest peripheral lymphoid organ of the body so it is essential to know their morphological quantitative aspects in order to identify potential abnormalities. The aim of this study was to determine the parameters stereological spleen in normal two species commonly used in research such as the guinea pig and rat, to obtain quantitative patterns of normality, which will serve as a basis for future studies morphofunctional. 5 spleens were used for each species (Cavia porcellus and Rattus novergicus, Sprague Dawley) obtained from biotery the Universidad de La Frontera, Temuco, Chile. The spleens were dissected and fixed in formalin buffered to 10 percent and the volume is determined by the of Scherle method. 5 pieces were obtained through Orientator and these were included in paraplast. Each piece was performed histological cuts of 3 mm thick and separated 200 µm each other, which were stained with H-E. The percentage of redpulp, whitepulp and marginal zone in the Guinea pig was: 65.14 percent, 21.96 percent and 12.67 percent respectively, and in the rat 53.9 percent pulpred, 25.75 percent whitepulp and 15.87 percent of marginal zone. The total number of follicles was 8.33 x 10²follicles and 5.73 x 10² follicles for the Guinea pig and rat, respectively. The results are consistent with those obtained by other authors might identify a pattern of quantitative percentage of splenic compartments of normality that could be considered for future studies morpho-functional.
Subject(s)
Animals , Rats , Spleen/anatomy & histology , Spleen/embryology , Guinea Pigs/anatomy & histology , Guinea Pigs/embryology , Guinea Pigs/blood , Rats/anatomy & histology , Rats/blood摘要
To compare the proportions of white and red pulps of the human spleen during the fetal period. We performed this study in the Department of Anatomy and Pathology of Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey, from the period between 2002-2003. Spleens from 137 dead fetuses aged between 9 and 40 weeks were embedded into paraffin blocks following classical histological steps and stained with hematoxylin and eosin. White and red pulps could be differentiated only in 25 cases [13 males, 12 females]. The proportions of the areas of white and red pulps [the trabeculae were included into the red pulp and the groups of lymphocytes were included into the white pulp] were estimated by point counting method on the sections taken from different parts of the spleens by systematic randomized sampling technique. It has been ascertained that the white pulp has been distinguished from 20th week onwards during the fetal period. The proportion of the white pulp area has been found to be 22.3% [of total white and red pulp areas] at the 20th week and has come to 37.6% at the 40th week. Concerning the trimesters, the proportion of the white pulp area has been found to be 30% [of total white and red pulp areas] at the 2nd trimester and has come to 36% at full term. While the white pulp area had a positive correlation with the gestational age [r: 0.34], the red pulp area had a negative one [r: -0.34]. No difference has been found among gender. Reference values have been obtained about the proportions of white and red pulp areas of human fetal spleen
Subject(s)
Humans , Male , Female , Spleen/embryology , Spleen/growth & development , Spleen/ultrastructure , Fetal Development/physiology , Pregnancy Trimesters , Reference Values , Time Factors , Gestational Age摘要
Los bazos accesorios son un hallazgo frecuente en autopsias, pero su identificación ecográfica es dificultosa. Los datos sobre su incidencia son escasos en la literatura y están referidos fundamentalmente a técnicas radioisotópicas. En un total de 5.000 ecografías se encontraron 14 bazos accesorios (aproximadamente 1 de cada 350 pacientes). La mayoría de los esplenúnculos estaban localizados en el hilio esplénico. En ningún caso hubo signos o síntomas relacionados con la anormalidad