Graves' ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts
Arch. endocrinol. metab. (Online)
; 62(3): 366-369, May-June 2018. graf
Article
ي En
| LILACS
| ID: biblio-1038490
المكتبة المسؤولة:
BR1.1
ABSTRACT
ABSTRACT Objective:
Graves' ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. Materials andmethods:
Orbital fibroblasts collected during orbital decompression of a female patient with moderately severe/severe GO were cultivated and treated with 10 nM and 100 nM dexamethasone (Dex). rRARα gene expression in the treated and untreated cells was then compared.Results:
Fibroblast RARα expression was not affected by 100 nM Dex. On the other hand, RARα expression was 24% lower in cells treated with 10 nM Dex (p < 0.05).Conclusions:
Orbital fibroblasts from a GO patient expressed the RARα gene, which was unaffected by higher, but decreased with lower doses of glucocorticoid.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Orbit
/
Dexamethasone
/
Gene Expression
/
Graves Ophthalmopathy
/
Fibroblasts
/
Glucocorticoids
المحددات:
Humans
اللغة:
En
مجلة:
Arch. endocrinol. metab. (Online)
موضوع المجلة:
ENDOCRINOLOGIA
/
METABOLISMO
السنة:
2018
نوع:
Article