Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 41(5): 419-427, Sept.-Oct. 2019. tab, graf
Article
ي En
| LILACS
| ID: biblio-1039115
المكتبة المسؤولة:
BR1.1
ABSTRACT
Objective:
To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflammatory and neurotrophic factors.Methods:
Adult male Wistar rats were subjected to an animal model of mania. After the open-field test, they were given LPS to induce systemic immune activation. Subsequently, the animals' blood was collected, and their serum levels of brain-derived neurotrophic factor and inflammatory markers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1β, IL-10, and inducible nitric oxide synthase [iNOS]) were measured.Results:
LDX induced hyperactivity in the animals, but no inflammatory marker levels increased except brain-derived neurotrophic factor (BDNF). Li had no effect on serum BDNF levels but prevented iNOS levels from increasing in animals subjected to immune activation.Conclusion:
Although Li prevented an LPS-induced increase in serum iNOS levels, its potential anti-inflammatory effects in this animal model of mania were conflicting.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Bipolar Disorder
/
Disease Models, Animal
/
Lisdexamfetamine Dimesylate
/
Lithium
/
Anti-Inflammatory Agents
/
Nerve Growth Factors
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
En
مجلة:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
موضوع المجلة:
PSIQUIATRIA
السنة:
2019
نوع:
Article