Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Rev. Soc. Bras. Med. Trop
; 50(5): 689-692, Sept.-Oct. 2017. graf
Article
ي En
| LILACS
| ID: biblio-1041423
المكتبة المسؤولة:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.METHODS:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.RESULTS:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.CONCLUSIONS:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
CD4-Positive T-Lymphocytes
/
Chagas Cardiomyopathy
/
CD8-Positive T-Lymphocytes
/
Receptors, CCR
المحددات:
Aged
/
Female
/
Humans
/
Male
اللغة:
En
مجلة:
Rev. Soc. Bras. Med. Trop
موضوع المجلة:
MEDICINA TROPICAL
السنة:
2017
نوع:
Article