Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;51(1): 94-98, Jan.-Feb. 2018. tab, graf
Article
ي En
| LILACS
| ID: biblio-1041447
المكتبة المسؤولة:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.METHODS:
Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.RESULTS:
Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.CONCLUSIONS:
BCG responsiveness does not affect protection against atopy.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Immunoglobulin E
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BCG Vaccine
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Immunization, Secondary
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Interferon-gamma
نوع الدراسة:
Clinical_trials
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Prognostic_studies
المحددات:
Female
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Humans
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Male
اللغة:
En
مجلة:
Jornal brasileiro de medicina tropical
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Rev Soc Bras Med Trop
/
Rev. Soc. Bras. Med. Trop
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Rev. Soc. Bras. Med. Trop. (Online)
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Revista da Sociedade Brasileira de Medicina Tropical (Impresso)
موضوع المجلة:
MEDICINA TROPICAL
السنة:
2018
نوع:
Article