Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;52: e20180453, 2019. tab, graf
Article
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| LILACS
| ID: biblio-1041531
المكتبة المسؤولة:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria.METHODS:
This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study.RESULTS:
Some cases of QT prolongation were observed. However, no TdP was found.CONCLUSIONS:
AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Quinolines
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Long QT Syndrome
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Malaria, Falciparum
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Artemisinins
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Antimalarials
نوع الدراسة:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
المحددات:
Adult
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Female
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Humans
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Male
اللغة:
En
مجلة:
Rev. Soc. Bras. Med. Trop
موضوع المجلة:
MEDICINA TROPICAL
السنة:
2019
نوع:
Article