In-vitro cardiovascular protective activity of a new achillinoside from Achillea alpina

Zhou, Fei; Li, Song; Yang, Jian; Ding, Jiawang; He, Chao; Teng, Lin

Zhou, Fei; Li, Song; Yang, Jian; Ding, Jiawang; He, Chao; Teng, Lin.

Affiliation

Zhou, Fei; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN
Li, Song; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN
Yang, Jian; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN
Ding, Jiawang; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN
He, Chao; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN
Teng, Lin; China Three Gorges University. The First College of Clinical Medical Sciences. Institute of Cardiovascular Diseases. Yichang. CN

Rev. bras. farmacogn ; 29(4): 445-448, July-Aug. 2019. graf

Article ي En | LILACS | ID: biblio-1042279

المكتبة المسؤولة: BR1.1

ABSTRACT

ABSTRACT

Abstract Achillinoside was isolated from methanol extract of Achillea alpina L., Asteraceae. The structure of the compound was characterized based on various spectrum data, including IR, HR-ESI-MS, 1D and 2D NMR. The cardiovascular protective effect of achillinoside was tested on H2O2-induced H9c2 cells. In our research, achillinoside could increase the cell viability dose-dependently in H2O2-induced H9c2 cells. In addition, the levels of caspase-3/9 cells were significantly decreased in H2O2 and achillinoside incubated H9c2 cells.

Key words

Achillinoside; Apoptosis inhibition; H9c2 cells; Spectroscopic analysis

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