Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study
Pesqui. bras. odontopediatria clín. integr
; 20: e5096, 2020. tab
Article
ي En
| LILACS, BBO
| ID: biblio-1056880
المكتبة المسؤولة:
BR1264.1
ABSTRACT
Abstract Objective:
To compare soluble HLA-C and HLA-DR molecules present in the plasma of orofacial cleft and non-orofacial cleft populations. Material andMethods:
Orofacial cleft patients were recruited using an accidental sampling approach (n=15). Peripheral blood was collected from the participants and processed for Enzyme Linked Immunosorbent Assay (ELISA) against HLA-C and HLA-DR with specific antibodies. The absorbance was calculated utilizing ELISA reader. Data were statistically analyzed using an independent t-test to compare the disease and control groups.Results:
The levels of soluble HLA-C and HLA-DR were significantly higher in the diseased group compared to the control group (p<0.05).Conclusion:
The role of HLA molecules in non-communicable disease and congenital anomalies, particularly orofacial cleft, remains speculative despite the positive results of this study and those of previous investigations. It suggests that the variables examined may affect specific pathways involved in the pathogenesis of orofacial cleft, and predispose the individuals concerned to the oral cleft.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
HLA-C Antigens
/
HLA-DR Antigens
/
Case-Control Studies
/
Homeopathic Pathogenesy
/
Cleft Lip
نوع الدراسة:
Observational_studies
المحددات:
Adolescent
/
Child
/
Female
/
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Pesqui. bras. odontopediatria clín. integr
موضوع المجلة:
ODONTOLOGIA
السنة:
2020
نوع:
Article