Non-inferiority clinical trials: importance and applications in health sciences
Braz. oral res. (Online)
; 34(supl.2): e072, 2020. graf
Article
ي En
| LILACS, BBO
| ID: biblio-1132738
المكتبة المسؤولة:
BR1.1
ABSTRACT
Abstract Non-inferiority randomized clinical trials are indicated when it is intended to prove that an experimental group is not inferior to a control group by more than a margin of non-inferiority. However, this type of study differs from traditional randomized clinical trials (superiority studies) because they have particularities that impact on the formulation of hypothesis to be tested, experimental design (non-inferiority margin determination, adapted sample size calculation, sensitivity of the study and data final analysis) and also on the presentation of data when writing the manuscript. Therefore, this article aims to present and discuss the particularities of non-inferiority clinical studies, since these requirements are fundamental to guarantee the validity of the conclusions of this type of study.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Research Design
نوع الدراسة:
Clinical_trials
اللغة:
En
مجلة:
Braz. oral res. (Online)
موضوع المجلة:
ODONTOLOGIA
السنة:
2020
نوع:
Article