Myasthenia gravis and COVID-19: a systematic review of case reports and case series
Rev. patol. trop
;
50(2): 1-20, jun. 2021. ilus
مقالة
ي الانجليزية
| LILACS
| ID: biblio-1254419
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disease involving neuromuscular transmission and possible respiratory failure when concomitant with COVID-19. The aim of this study was to analyze the need for ventilatory support (VS), length of hospital stay (LOS) and mortality in patients diagnosed with MG and COVID-19. In this systematic review, PubMed, SciELO, LILACS, MEDLINE and IBECS databases were searched for primary studies published from January 2010 to March 2021, with no language restrictions. Fourteen eligible studies were identified. The main factor associated with the need for VS was the use of antibiotics other than azithromycin (AZM) for the treatment of COVID-19 (RR 1.60; 95% CI 1.202.91; p = 0.009). Patients who used hydroxychloroquine (HCQ) and AZM had almost twice the risk of needing invasive ventilatory support (IVS) (RR 1.94; 95% CI 1.07-3.52; p = 0.16). There were nonsignificant trends towards less need for IVS in patients who used intravenous immunoglobulin (IVIg) and corticosteroid therapy (RR 0.54; 95% CI 0.093.26; p = 0.60). There was a trend towards shorter LOS in patients who received therapy with IVIg and corticosteroid therapy [8 (5 - 8) vs 19 (12.223.7); p = 0.007]. 10.3% (n = 4/39) died and 100% did not use IVIg or IVIg and prednisone. There was a non-significant trend towards higher mortality in patients who used AZM (RR 2.55; 95% CI 0.2630.02; p = 0.60). IVIg and corticotherapy presented themselves as a favorable alternative in relation to the outcomes. KEY WORDS Coronavirus infections; length of stay; Myasthenia gravis; Respiratory insufficiency.
النص الكامل:
متاح
الفهرس:
LILACS الأمريكتان
الموضوع الرئيسي:
Mortality
/
Coronavirus
/
Interactive Ventilatory Support
/
Length of Stay
/
Myasthenia Gravis
نوع الدراسة:
Prognostic_studies
/
تقييم المراجعات المنهجية
المحددات:
البشر
اللغة:
الانجليزية
مجلة:
Rev. patol. trop
موضوع المجلة:
طب المناطق الحارة
/
علم الأمراض
السنة:
2021
نوع:
مقالة
بلد الانتماء:
المؤسسة/الدولة:
Pontifícia Universidade Católica de Minas Gerais/BR
المراجع ذات الصلة
MEDLINE
...
LILACS
LIS