Response of patients with acute respiratory failure caused by COVID-19 to awake-prone position outside the intensive care unit based on pulmonary involvement
Clinics
; 76: e3368, 2021. tab, graf
Article
ي En
| LILACS
| ID: biblio-1350605
المكتبة المسؤولة:
BR1.1
ABSTRACT
OBJECTIVES:
Since there are difficulties in establishing effective treatments for COVID-19, a vital way to reduce mortality is an early intervention to prevent disease progression. This study aimed to evaluate the performance of patients with COVID-19 with acute hypoxic respiratory failure according to pulmonary impairment in the awake-prone position, outside of the intensive care unit (ICU).METHODS:
A prospective observational cohort study was conducted on COVID-19 patients under noninvasive respiratory support. Clinical and laboratory data were obtained for each patient before the treatment and after they were placed in the awake-prone position. To identify responders and non-responders after the first prone maneuver, receiver operating characteristic curves with sensitivity and specificity of the PaO2/FiO2 and SpO2/FiO2 indices were analyzed. The maneuver was considered positive if the patient did not require endotracheal intubation for ventilatory assistance.RESULTS:
Forty-eight patients were included, and 64.6% were categorized as responders. The SpO2/FiO2 index was effective for predicting endotracheal intubation in COVID-19 patients regardless of lung parenchymal damage (area under the curve 0.84, cutoff point 165, sensitivity 85%, specificity 75%). Responders had better outcomes with lower hospital mortality (hazard ratio [HR]=0.107, 95% confidence interval [CI] 0.012-0.93) and a shorter length of stay (median difference 6 days, HR=0.30, 95% CI 0.13-0.66) after adjusting for age, body mass index, sex, and comorbidities.CONCLUSIONS:
The awake-prone position for COVID-19 patients outside the ICU can improve oxygenation and clinical outcomes regardless of the extent of pulmonary impairment. Furthermore, the SpO2/FiO2 index discriminates responders from non-responders to the prone maneuver predicting endotracheal intubation with a cutoff under or below 165.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Respiratory Distress Syndrome, Newborn
/
Respiratory Insufficiency
/
COVID-19
نوع الدراسة:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Clinics
موضوع المجلة:
MEDICINA
السنة:
2021
نوع:
Article