Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function
Braz. j. infect. dis
; Braz. j. infect. dis;26(1): 101701, 2022. graf
Article
ي En
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LILACS-Express
| LILACS
| ID: biblio-1364542
المكتبة المسؤولة:
BR1.1
ABSTRACT
Abstract Severe lactic acidosis, a mitochondrial toxicity caused by the recommended standard dosage of linezolid (LZD), may occur in patients with impaired renal function. We describe an adult male who underwent kidney transplantation with stably impaired renal function, severe dyspnea, and abdominal discomfort. He received a standard oral dose of LZD (600 mg twice daily) and azithromycin for three weeks with a reduced immunosuppressant dose due to pulmonary non-tuberculosis mycobacterial infection. He was alert and afebrile, with a blood pressure of 140/60 mmHg. Pertinent laboratory data showed pH 7.12, PaCO2 13.6 mmHg; HCO3- 4.3 mmol/L and serum lactate 18.4 mmol/L. His trough serum LZD concentration reached toxic levels (21.4 μg/mL). With hemodialysis, his clinical symptoms improved, with a decline in serum LZD (9.8μg/mL) and lactate (3.2 mmol/L). Chronic standard dose LZD in patients with impaired renal function can lead to life-threatening lactic acidosis, especially in coexisting conditions that reduce LZD metabolism.
النص الكامل:
1
الفهرس:
LILACS
نوع الدراسة:
Risk_factors_studies
اللغة:
En
مجلة:
Braz. j. infect. dis
موضوع المجلة:
DOENCAS TRANSMISSIVEIS
السنة:
2022
نوع:
Article