Primary culture macrophages from fish as potential experimental model in toxicity studies with multiwalled carbon nanotubes
Acta sci., Biol. sci
; 43: e52612, 2021. graf, ilus
Article
ي En
| LILACS, VETINDEX
| ID: biblio-1460984
المكتبة المسؤولة:
BR68.1
الموقع: BR68.1
ABSTRACT
Multiwalled carbon nanotube (MWCNT) has been broadly used in several sectors of society. This material when exposed to the environment might reach the aquatic animals and cause toxic effects. Here, it was evaluated the MWCNTs toxicity in melanomacrophages primary culture that was submitted to 1 µ gm L-1 MWCNTs for 24 hours. After exposition to MWCNT, 48 and 59% liver and spleen melanomacrophages were healthy, respectively. The control group presented 85% viability. Phagocytosis activity of melanomacrophages was observed by presence of black inclusions in cytoplasm. The findings indicate MWCNT was cytotoxic to melanomacrophages, where its release and effect into aquatic environment must be more studied. Finally, the melanomacrophages present large potential as experimental model for evaluation of carbon-based nanomaterial toxicity.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Phagocytosis
/
Nanotubes, Carbon
/
Fishes
/
Macrophages
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
En
مجلة:
Acta sci., Biol. sci
موضوع المجلة:
BIOLOGIA
السنة:
2021
نوع:
Article