Megavoltage radiotherapy effects on organs of the reticuloendothelial system
Acta cir. bras
; Acta cir. bras;38: e384123, 2023. tab, ilus
Article
ي En
| LILACS, VETINDEX
| ID: biblio-1519878
المكتبة المسؤولة:
BR68.1
الموقع: BR68.1
ABSTRACT
Purpose:
To study the uptake capacity of cells from the reticuloendothelial system after irradiation with high-energy X-rays.Methods:
Eighteen male Wistar rats were distributed in three groups group A (n = 6) control, unirradiated animals studied alongside animals from group B; group B (n = 6) and group C (n = 6) animals irradiated and studied after 24 and 48 hours, respectively. The rats were anesthetized and placed on a 10 MV linear accelerator. Next, they were irradiated in the abdominal region, with 8 Gy. Twenty-four (groups A and B) and 48 hours later (group C), a colloidal carbon solution (1 mL/kg) was intravenously injected in the tail vein. Fifty minutes later, the spleens and livers were withdrawn and prepared to be studied. Kupffer cells and splenic macrophages containing carbon pigments were counted in an optical microscope. Arithmetic means were calculated for each group and compared among them.Results:
X-rays were associated with a reduced number of Kupffer cells containing colloidal carbon, proliferation and enlargement of biliary ducts, hypoplasia, and hepatocyte necrosis. In the irradiated spleen, the colloidal carbon uptake was concentrated in the marginal zone around the white pulp, with an inexpressive uptake of pigments by macrophages from white and red pulps.Conclusions:
The X-rays in the rat abdomen are associated with a reduction in the Kupffer cells uptake of colloidal carbon, hepatocyte disorders, bile duct proliferation, and splenic uptake of colloidal carbon concentrated in the marginal zone.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Mononuclear Phagocyte System
/
Radiotherapy, High-Energy
/
Kupffer Cells
المحددات:
Animals
اللغة:
En
مجلة:
Acta Cir Bras
/
Acta cir. bras
/
Acta cir. bras. (Online)
/
Acta cirúrgica brasileira (Impresso)
موضوع المجلة:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
السنة:
2023
نوع:
Article