Blood transfusion-related immunomodulation
Clin. biomed. res
; 34(4): 333-341, 2014. ilus, tab
Article
ي En
| LILACS
| ID: biblio-834486
المكتبة المسؤولة:
BR18.1
ABSTRACT
The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Blood Group Antigens
/
Blood Preservation
/
Blood Transfusion
/
Immunosuppression Therapy
/
Transplantation Tolerance
/
Leukocyte Reduction Procedures
/
Immunomodulation
/
HLA Antigens
اللغة:
En
مجلة:
Clin. biomed. res
موضوع المجلة:
MEDICINA
السنة:
2014
نوع:
Article