Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil
Mem. Inst. Oswaldo Cruz
;
112(4): 255-259, Apr. 2017. tab, graf
مقالة
ي الانجليزية
| LILACS
| ID: biblio-841784
ABSTRACT
BACKGROUND Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxicity, which may result in discontinuation of the therapy. OBJECTIVES The aim of this study was (i) to estimate prevalence of HCV and HIV in a group of patients newly diagnosed with active TB in a public reference hospital in Porto Alegre and (ii) to compare demographic, behavioural, and clinical characteristics of patients in relation to their HCV infection status. METHODS One hundred and thirty-eight patients with TB were tested for anti-HCV antibody, HCV RNA, and anti-HIV1/2 antibody markers. HCV RNA from real-time polymerase chain reaction (PCR)-positive samples was submitted to reverse transcription and PCR amplification. The 5′ non-coding region of the HCV genome was sequenced, and genotypes of HCV isolates were determined. FINDINGS Anti-HCV antibody, HCV RNA, and anti-HIV antibodies were detected in 27 [20%; 95% confidence interval (CI), 13-26%], 17 (12%; 95% CI, 7-18%), and 34 (25%; 95% CI, 17-32%) patients, respectively. HCV isolates belonged to genotypes 1 (n = 12) and 3 (n = 4). Some characteristics were significantly more frequent in patients infected with HCV. Among them, non-white individuals, alcoholics, users of illicit drugs, imprisoned individuals, and those with history of previous TB episode were more commonly infected with HCV (p < 0.05). MAIN CONCLUSIONS HCV screening, including detection of anti-HCV antibody and HCV RNA, will be important to improving the management of co-infected patients, given their increased risk of developing TB treatment-related hepatotoxicity.
النص الكامل:
متاح
الفهرس:
LILACS الأمريكتان
الموضوع الرئيسي:
Tuberculosis
/
HIV Antibodies
/
HIV Infections
/
Hepatitis C
/
Coinfection
نوع الدراسة:
دراسة تشخيصية
/
دراسة الانتشار
/
عوامل الخطر
المحددات:
مراهق
/
راشد/بالغ
/
كبير في السن
/
أنثى
/
البشر
/
ذكر
البلد/الأقليم حسب الموضوع:
جنوب امريكا
/
البرازيل
اللغة:
الانجليزية
مجلة:
Mem. Inst. Oswaldo Cruz
موضوع المجلة:
طب المناطق الحارة
/
علم الطفيليات
السنة:
2017
نوع:
مقالة
/
وثيقة المشروع
بلد الانتماء:
المؤسسة/الدولة:
Secretaria Estadual da Saúde do Rio Grande do Sul/BR
المراجع ذات الصلة
MEDLINE
...
LILACS
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