Antimalarial drug resistance in vitro studies against Plasmodium falciparum in Punjab, Pakistan
Medical Forum Monthly. 2011; 22 (6): 27-32
ي En
| IMEMR
| ID: emr-124606
المكتبة المسؤولة:
EMRO
ABSTRACT
Antimalarial drug resistance was checked against Plasmodium falciparum in Punjab Pakistan, Prospective nonrandomized descriptive study. Study was conducted in seven districts [Muzaffargarh, D.G.Khan, Jhang, Sheikhupura, Faisalabad, Lahore and Multan] of Punjab, Pakistan during the transmission season from July-November of 2003 to 2008. Out of total positive for P.falciparum 612 [228+192+192] subjects were enrolled for study as per eligibility criteria of World Health Organization [WHO] and in vitro standard test kit was used for study. Differences in proportions and its significance were analyzed by chi-square tests. Resistance [%] to chloroquine was noted higher in males [79.5%] and in females [20.4%]. Highest resistance [%] 31.8 was detected in 6-15 years age group. Same resistance [%] trend was observed in basoquine for males [72], females [28.35], for age groups 6-15 years [41.7] and total was 34.8. Sulphadoxine-pyrimethamine found highly effective with only 5.7% resistance. Trend of resistance [%] in male, female and among different age groups was found same in chloroquine and basoquine. Differences among the resistance [%]sulphadoxine-pyrimethamme and chloroquine or basoquine was highly significant [p<0.00l] and between basoquine and chloroquine resistance difference was non significant [p>0.177]. Male of age group 6-15 years having 6000 parasite >/= microl must be treated on priority basis by artesunate combination therapy [ACT]. Chloroquine was less effective than sulfadoxine-pyrimethamine [adjusted odds ratio [OR], 6.4; 95% confidence interval [CI], 2.4-17.0; P<.001] and basoquine [adjusted OR, 8.4; 95% CI, 2.0-36.5; P = .004]. Chloroquine and sulfadoxine-pyrimethamine were equivalent in efficacy at day 28 [adjusted OR, 1.3; 95% CI, 0.3-7.0; P = .73]
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الفهرس:
IMEMR
الموضوع الرئيسي:
Pyrimethamine
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Sulfadoxine
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Drug Resistance
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Chloroquine
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Prospective Studies
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Drug Combinations
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Antimalarials
المحددات:
Female
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Humans
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Male
اللغة:
En
مجلة:
Med. Forum Mon.
السنة:
2011