Comparative study of plant extracts Nigella sativa [Black seed] and Ukraine with Antiviral drug: on DNA and RNA Viruses

ABSTRACT

Studies were conducted to determine the antiviral activities of synthetic [Troamantadine hydrochloride] and a plant extracts [a commonly used oil extract of Nigella satsiva. and Ukrain] on Herpes simplex virus type-l [DNA] and Polio virus type-l [RNA] virus and this required the determination of the toxicity level of these substances on cell culture and detection of the antiviral activity on tissue culture [Vero cells]. Data indicated that Ukrain is effective on Polio virus because it has significant value as antiviral agent after adsorption on vero cells, but Nigella has a virucidal effect on polio virus. At the same time, Nigella and Troamantadine have a virucidal effect on Herpes virus, but the Troamantadine hydrochloride gave a significant effect as antiviral agent after adsorption of Herpes virus [extra cellular and intra cellular]