Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy
Arch. med. res
; 24(1): 1-6, mar. 1993. ilus, tab
Article
ي En
| LILACS
| ID: lil-176994
المكتبة المسؤولة:
MX1.1
ABSTRACT
Forty unrelated Mexican patients with Duchenne/Backer muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone oxons described by Chamberlain et al. and beggs et al. The percentage of deletions was 52.5 percent, and the majority of them (86.3 percent) were located at the hot spot deletion region which encompasses exons 44 - 55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity
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الفهرس:
LILACS
الموضوع الرئيسي:
Population
/
Population Forecast
/
Genetics, Population
/
Genetic Diseases, Inborn
/
Muscular Dystrophies
المحددات:
Adolescent
/
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Mexico
اللغة:
En
مجلة:
Arch. med. res
موضوع المجلة:
MEDICINA
السنة:
1993
نوع:
Article