Alteraciones de la mecanosensibilidad gastrica, del vaciamiento gastrico y de la electrograstrografia en pacientes con dispepsia no organica (DNO) / Abnormalities in gastric mechano sensitivity, gastric emptying and electrogastrography in non organic dyspepsia (NOD)

ABSTRACT

The aim to study the alterations in mechanosensitivity gastric emptying, and electrogastrography (E.G.G.) in a population of patients suffering from N.O.D. eighteen controls (9 males, 9 females, mean age 49.33 years oldpatients with N.O.D. (22 males, 21 females, mean age 55.72 years old, SEM 2.87, range 17-86) were studied. Gastric mechano-sensitivity with a latex balloon of low compliance inflated "in fasic"was investigated, and intra balloon pressure was recorded. Gastric emptyng with a mixed meal marked with 99 Tc in the solid fase, containing 250 Cal, was studiet. E.G.G. was studiet using two skin surface electrodes Ag-2C1Ag placed on epigastric area following a probalistic antral axe. Only dominant frequency in each block was considered, and percent of total abnormalities on total recording time lesser than 2 c.p.m or more than 4 c.p.m. was considered. Recordings were taken during fast time during 30 minutes, and 30 minutes after a meal containing 250 Cal. Analysis with F.F.T, and spectral running.

Results:

In 67.92 percent a delay in gastric emptying was observed 56.3 percent did not complete 700 ml. of balloon inflation because of pain, Vs 16.8 percent in controls (p<0.001) The slopes of intra-balloon preassure were not differents in both groups. (Variance, F-NS). Mean E.C.A was 2.99 c.p.m. in control, Vs 3.46 in fasting and 3.64 in postprandial period in N.O.D. (p=NS) Differences in fasting and postprandial percent of arrhytmias total time recording were significatives in N.O.D. ("t". 0.02>0.01). Twenty porcent of controls showed isolated tachygastria, but dominant frecuencies never were higher than 6 c.p.m and never last more than 8 percent of the total recording time. Sixty eight point seventy five porcent of N.O.D. showed arrhytmias, 48 percent of tachygastrias were in the range 30-60 percent of total recording time. No differences in gastric emptying between patient presenting pain with=<700ml. and <700ml. of balloon inflation were seen. Patients with sensorial treshold=<700ml. showeed less frequent tachigastria (0.01Patients with delayed gastric emptying showed more frequent tachygastria (94.7 percent, 0.05Conclusions: a) E.G.G. abnormalities would more frequents in "motor"subpopulation; b) No association between abnormalities in gastric emptying abnormal tresholds in mechanosensitivity and/or E.G.G. and any clinical subtype of Dyspepsia can be showed; h) although gastric arrhytmia was...