Structural biology of chemokine receptors
Biol. Res
; 32(4): 263-72, 1999.
Article
ي En
| LILACS
| ID: lil-264239
المكتبة المسؤولة:
BR1.1
RESUMO
Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition and signal transduction are currently being investigated. High-resolution X-ray diffraction and NMR spectroscopy of chemokines indicate that all these peptides exhibit a common folding pattern, in spite of its low degree of primary-sequence homology. Chemokines' functional motifs have been identified by mutagenesis studies, and a possible mechanism for receptor recognition and activation is proposed, but high-resolution structure data of chemokine receptors is not yet available. Studies with receptor chimeras have identified the putative extracellular domains as the major selectivity determinants. Single-amino acid substitutions in the extracellular domains produce profound changes in receptor specificity, suggesting that motifs in these domains operate as a restrictive barrier to a common activation motif. Similarly HIV-1 usage of chemokine receptors involves interaction of one or more extracellular domains of the receptor with conserved and variable domains on the viral envelope protein gp 120, indicating a highly complex interaction. Elucidating the structural requirements for receptor interaction with chemokines and with HIV-1 will provide important insights into understanding the mechanisms of chemokine recognition and receptor activation. In addition, this information can greatly facilitate the design of effective inmunomodulatory and anti-HIV-1 therapeutic agents
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
CD4-Positive T-Lymphocytes
/
HIV
/
Receptors, Chemokine
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
Biol Res
/
Biol. Res
/
Biol. Res. (Online)
/
Biological Research
موضوع المجلة:
BIOLOGIA
السنة:
1999
نوع:
Article