Cells with dyskeratotic inclusions in smears from cervix uteri infected by human papillomavirus

ABSTRACT

An addictional feature has been reported in cervical smears from patients with human papillomavirus (HPV) infection the "cell inside another cell", that shows inclusion bodies in addiction to a nuclear smudging (cell with dyskeratotic inclusions CDI). We observed smears from 129 patients with diagnosis of Hpv infection of the cervix uteri, stained by Papanicolaou technique. Koilocytes were observed in 48,8 porcento of the patients, and CDI in 30,2 porcento of them. CDI was presented by 19,3 porcento of the patients. The CDI could not be related to a special type of HPV, therefore it is not a parameter for estimation of the oncogenic risk. Further studies are needed to clarify if CDI could be other indirect feature suggestive of HPV infection.