Nutritional status in relation to the efficacy of the rhesus-human reassortant, tetravalent rotavirus vaccine (rrv-tv) in infants from Belém, Para state, Brazil
Rev. Inst. Med. Trop. Säo Paulo
; Rev. Inst. Med. Trop. Säo Paulo;44(1): 13-16, Jan.-Feb. 2002. tab
Article
ي En
| LILACS
| ID: lil-307236
المكتبة المسؤولة:
BR1.1
RESUMO
The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 10(4) pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRV-TV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38 percent (p = 0.04) and 40 percent (p = 0.04) for all- and- pure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43 percent, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices <= -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Rotavirus Infections
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Vaccines, Attenuated
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Nutritional Status
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Rotavirus
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Rotavirus Vaccines
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Diarrhea
نوع الدراسة:
Clinical_trials
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Prognostic_studies
المحددات:
Animals
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Humans
البلد/الأقليم حسب الموضوع:
America do sul
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Brasil
اللغة:
En
مجلة:
Journal of the São Paulo Institute of Tropical Medicine
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Rev Inst Med Trop Sao Paulo
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Rev. Inst. Med. Trop. São Paulo (Online)
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Rev. Inst. Med. Trop. Säo Paulo
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Revista do Instituto de Medicina Tropical de Säo Paulo (Impresso)
موضوع المجلة:
MEDICINA TROPICAL
السنة:
2002
نوع:
Article