CD4 T cells producing pro-inflammatory interleukin-17 mediate high pathology in schistosomiasis
Mem. Inst. Oswaldo Cruz
; 101(supl.1): 327-330, Oct. 2006. ilus
Article
ي En
| LILACS
| ID: lil-441268
المكتبة المسؤولة:
BR1.1
ABSTRACT
In murine schistosomiasis mansoni, pronounced CD4 T cell-mediated, egg-induced, hepato-intestinal immunopathology and death, whether genetically determined or elicited experimentally, are associated with failure to down-regulate a net pro-inflammatory immune response. Important evidence contributing to this notion comes from the observation that immunization with schistosome egg antigens in CFA (SEA/CFA) causes low pathology C57BL/6 mice to develop an exacerbated form of disease and death in a cytokine milieu characterized by elevated interferon (IFN)-gamma levels. Since such a pro-inflammatory environment presumes a signaling pathway involving interleukin (IL)-12, the SEA/CFA immunization model was used to examine the extent of hepatic immunopathology in the absence of this cytokine. Surprisingly, the IL-12p40 subunit was an absolute requirement for the development of exacerbated disease, whereas the IL-12p35 subunit was not. Moreover, significantly elevated in vitro production of IL-17, but not of IFN-gamma, correlated with the high pathology, and neutralization of IL-17 in vivo resulted in a significant reduction of hepatic inflammation. Our findings clearly demonstrate the pathogenic potential of the novel IL-17-producing T cell subpopulation (ThIL-17), previously shown to mediate chronic inflammation in autoimmune disease. They also imply that IL-23, but not IL-12, is the critical signal necessary to support the pro-inflammatory ThIL-17 subset involved in high pathology schistosomiasis.
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Schistosoma mansoni
/
Schistosomiasis
/
Inflammation
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
En
مجلة:
Mem. Inst. Oswaldo Cruz
موضوع المجلة:
MEDICINA TROPICAL
/
PARASITOLOGIA
السنة:
2006
نوع:
Article
/
Project document