Short-interfering RNAs as antivirals against rabies
Braz. j. infect. dis
; 11(2): 224-225, Apr. 2007.
Article
ي En
| LILACS
| ID: lil-454723
المكتبة المسؤولة:
BR1.1
ABSTRACT
This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Rabies virus
/
Virus Replication
/
RNA, Small Interfering
المحددات:
Animals
اللغة:
En
مجلة:
Braz. j. infect. dis
موضوع المجلة:
DOENCAS TRANSMISSIVEIS
السنة:
2007
نوع:
Article