Genotyping of methicillin-resistant Staphylococcus aureus isolates obtained in the Northeast region of Brazil
Braz. j. med. biol. res
;
42(10): 877-881, Oct. 2009. ilus
مقالة
ي الانجليزية
| LILACS
| ID: lil-526184
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) is a major agent of hospital infections worldwide. In Brazil, a multiresistant MRSA lineage (ST239-SCCmecIIIA), the so-called Brazilian epidemic clone (BEC), has predominated in all regions. However, an increase in nosocomial infections caused by non-multiresistant MRSA clones has recently been observed. In the present study, 45 clinical isolates of MRSA obtained from a university hospital located in Natal city, Brazil, were identified by standard laboratory methods and molecularly characterized using staphylococcal chromosome cassette mec (SCCmec) typing and pulsed-field gel electrophoresis. Antimicrobial susceptibility testing was carried out using CLSI methods. The MRSA isolates studied displayed a total of 8 different pulsed-field gel electrophoresis patterns (types A to H) with predominance (73 percent) of pattern A (BEC-related). However, MRSA harboring SCCmec type IV were also identified, 3 (7 percent) of which were genetically related to the pediatric clone - USA800 (ST5-SCCmecIV). In addition, we found a considerable genetic diversity within BEC isolates. MRSA displaying SCCmecIV are frequently susceptible to the majority of non-β-lactam antibiotics. However, emergence of multiresistant variants of USA800 was detected.
النص الكامل:
متاح
الفهرس:
LILACS الأمريكتان
الموضوع الرئيسي:
Genetic Variation
/
Methicillin-Resistant Staphylococcus aureus
المحددات:
البشر
البلد/الأقليم حسب الموضوع:
جنوب امريكا
/
البرازيل
اللغة:
الانجليزية
مجلة:
Braz. j. med. biol. res
موضوع المجلة:
علم الاحياء
/
الطب
السنة:
2009
نوع:
مقالة
/
وثيقة المشروع
بلد الانتماء:
المؤسسة/الدولة:
Universidade Federal do Rio Grande do Norte/BR
/
Universidade Federal do Rio de Janeiro/BR
المراجع ذات الصلة
MEDLINE
...
LILACS
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