Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Genet. mol. biol
; 34(4): 539-545, 2011. tab
Article
ي En
| LILACS
| ID: lil-605936
المكتبة المسؤولة:
BR1.1
ABSTRACT
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Polymorphism, Genetic
/
Population Characteristics
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ABO Blood-Group System
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Haplotypes
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Brazil
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Receptors, Complement 3b
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Amazonian Ecosystem
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Malaria
نوع الدراسة:
Prognostic_studies
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Risk_factors_studies
المحددات:
Female
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Humans
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Male
البلد/الأقليم حسب الموضوع:
America do sul
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Brasil
اللغة:
En
مجلة:
Genet. mol. biol
موضوع المجلة:
GENETICA
السنة:
2011
نوع:
Article
/
Project document