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Salivary IgA and periodontal treatment needs in diabetic patients
Branco-de-Almeida, Luciana Salles; Alves, Cláudia Maria Coêlho; Lopes, Fernanda Ferreira; Pereira, Adriana de Fátima Vasconcelos; Guerra, Rosane Nassar Meireles; Pereira, Antônio Luiz Amaral.
Affiliation
  • Branco-de-Almeida, Luciana Salles; University Center of Maranhão. Postgraduate Department. São Luís. BR
  • Alves, Cláudia Maria Coêlho; Federal University of Maranhão. Department of Dentistry II. São Luís. BR
  • Lopes, Fernanda Ferreira; Federal University of Maranhão. Department of Dentistry II. São Luís. BR
  • Pereira, Adriana de Fátima Vasconcelos; Federal University of Maranhão. Department of Dentistry II. São Luís. BR
  • Guerra, Rosane Nassar Meireles; Federal University of Maranhão. Department of Pathology. São Luís. BR
  • Pereira, Antônio Luiz Amaral; Federal University of Maranhão. Department of Dentistry II. São Luís. BR
Braz. oral res ; 25(6): 550-555, Nov.-Dec. 2011. graf, tab
Article ي En | LILACS | ID: lil-608025
المكتبة المسؤولة: BR1.1
ABSTRACT
Salivary IgA can serve as a first line of defense against pathogens that colonize and invade mucosal surfaces and may be protective against periodontal disease. The aim of this study was to assess salivary immunoglobulin A levels in diabetic and non-diabetic patients with different periodontal treatment needs. The Periodontal Screening & Recording (PSR) system was used to evaluate the periodontal treatment needs of 41 diabetic and 42 non-diabetic patients. Unstimulated whole saliva was collected from each patient immediately before clinical examination and stored at -20 °C until analysis. Salivary immunoglobulin A (s-IgA) levels were determined using an enzyme-linked immunosorbent assay, and values were expressed as optical density. Diabetic and non-diabetic patients were compared using clinical and laboratory data. PSR data indicated that periodontal disease was more frequent and more severe in diabetic patients. A higher prevalence of codes 3 and 4 was observed in diabetics as compared with non-diabetics (odds ratio = 2, P < 0.05). Furthermore, non-diabetic patients had more healthy sextants (code 0) than did diabetic patients. Over half of diabetic patients (∼54 percent) presented with s-IgA levels that were lower than the normal range (optical density from 0.4 nm to 0.6 nm; P < 0.05). In addition, diabetic patients showed a higher variability in s-IgA levels as compared with non-diabetic patients. In conclusion, diabetic individuals had lower s-IgA levels, more-frequent and more-severe periodontal disease, and a greater need for periodontal treatment as compared with non-diabetic patients.
الموضوعات
Key words

النص الكامل: 1 الفهرس: LILACS الموضوع الرئيسي: Periodontal Diseases / Saliva / Immunoglobulin A, Secretory / Diabetes Mellitus نوع الدراسة: Diagnostic_studies / Observational_studies / Risk_factors_studies المحددات: Adult / Female / Humans / Male اللغة: En مجلة: Braz. oral res موضوع المجلة: ODONTOLOGIA السنة: 2011 نوع: Article / Project document

النص الكامل: 1 الفهرس: LILACS الموضوع الرئيسي: Periodontal Diseases / Saliva / Immunoglobulin A, Secretory / Diabetes Mellitus نوع الدراسة: Diagnostic_studies / Observational_studies / Risk_factors_studies المحددات: Adult / Female / Humans / Male اللغة: En مجلة: Braz. oral res موضوع المجلة: ODONTOLOGIA السنة: 2011 نوع: Article / Project document