Expresión de marcadores de proliferación celular e invasión tisular en cáncer papilar del tiroides y su asociación con metástasis ganglionares / Expression of proliferation and invasion markers in papilary thyroid carcinoma with and without lymph node involvement
Rev. chil. endocrinol. diabetes
; 2(4): 204-209, oct. 2009. ilus, graf
Article
ي Es
| LILACS
| ID: lil-610269
المكتبة المسؤولة:
CL1.1
ABSTRACT
Background:
Several molecules that may have a role in tumor proliferation, differentiation and invasion, have been detected in thyroid carcinoma. Some of these molecules are NIS, c-MET, TIMP1 an ephrinB2.Aim:
To detect the presence of these molecules in tissue samples of thyroid carcinoma and relate their expression to the biological behavior of the tumor. Material andMethods:
Tissue samples were prospectively obtained from 35 patients operated for a papillary thyroid carcinoma. Twelve patients had regional lymph node involvement. NIS, c-MET, TIMP1 and EphrinB2 were detected by real time polymerase chain reaction(RT-PCR) and immunohistochemistry.Results:
The expression of markers by RT-PCR was non significantly higher among tumors with lymph node involvement. Immunohistochemistryshowed a significantly lower nuclear expression and a higher cytoplasmatic expression of EphrinB2 in tumors with lymph node involvement.Conclusions:
Immunohistochemical expression of EphrinB2 could be useful for the initial staging of papillary thyroid carcinoma.Key words
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الفهرس:
LILACS
الموضوع الرئيسي:
Thyroid Neoplasms
/
Adenocarcinoma, Papillary
المحددات:
Humans
اللغة:
Es
مجلة:
Rev. chil. endocrinol. diabetes
موضوع المجلة:
ENDOCRINOLOGIA
السنة:
2009
نوع:
Article