Methylparaben concentration in commercial Brazilian local anesthetics solutions
J. appl. oral sci
; 20(4): 444-448, July-Aug. 2012. ilus
Article
ي En
| LILACS
| ID: lil-650621
المكتبة المسؤولة:
BR1.1
ABSTRACT
OBJECTIVE:
To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL ANDMETHODS:
Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrilewater (7525 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1.RESULTS:
When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben.CONCLUSION:
1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Parabens
/
Preservatives, Pharmaceutical
/
Anesthetics, Local
نوع الدراسة:
Etiology_studies
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
America do sul
/
Brasil
اللغة:
En
مجلة:
J. appl. oral sci
موضوع المجلة:
ODONTOLOGIA
السنة:
2012
نوع:
Article