Cognition and biomarkers of oxidative stress in obstructive sleep apnea
Clinics
; 68(4): 449-455, abr. 2013. tab, graf
Article
ي En
| LILACS
| ID: lil-674234
المكتبة المسؤولة:
BR1.1
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate neuropsychological performance and biomarkers of oxidative stress in patients with obstructive sleep apnea and the relationships between these factors.METHODS:
This was an observational, cross-sectional study of 14 patients (36.0±6.5 years old) with obstructive sleep apnea and 13 controls (37.3±6.9 years old). All of the participants were clinically evaluated and underwent full-night polysomnography as well as neuropsychological tests. Blood samples were used to assay superoxide dismutase, catalase, glutathione and homocysteine, as well as vitamins E, C, B11 and B12.RESULTS:
The patients performed poorly relative to the controls on several neuropsychological tests, such as the attention test and tests of long-term memory and working memory/executive function. They also had lower levels of vitamin E (p<0.006), superoxide dismutase (p<0.001) and vitamin B11 (p<0.001), as well as higher concentrations of homocysteine (p<0.02). Serum concentrations of vitamin C, catalase, glutathione and vitamin B12 were unaltered. Vitamin E levels were related to performance in the backward digit span task (F = 15.9; p = 0.002) and this correlation remained after controlling for age and body mass index (F = 6.3, p = 0.01). A relationship between superoxide dismutase concentrations and executive non-perseveration errors in the Wisconsin Card Sorting Test (F = 7.9; p = 0.01) was also observed.CONCLUSIONS:
Decreased levels of antioxidants and lower performance on the neuropsychological tasks were observed in patients with obstructive sleep apnea. This study suggests that an imbalance between antioxidants and pro-oxidants may contribute to neuropsychological alterations in this patient population. .Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Cognition
/
Oxidative Stress
/
Sleep Apnea, Obstructive
نوع الدراسة:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
المحددات:
Adult
/
Aged
/
Female
/
Humans
/
Male
اللغة:
En
مجلة:
Clinics
موضوع المجلة:
MEDICINA
السنة:
2013
نوع:
Article