In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;47(1): 110-112, Jan-Feb/2014. tab
Article
ي En
| LILACS
| ID: lil-703166
المكتبة المسؤولة:
BR1.1
ABSTRACT
Introduction:
We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.Methods:
A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.Results:
The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI) 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.Conclusions:
Tigecycline may represent an alternative drug for the treatment of patients with severe malaria. .Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Plasmodium falciparum
/
Proteins
/
Minocycline
/
Antimalarials
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
America do sul
/
Brasil
اللغة:
En
مجلة:
Rev. Soc. Bras. Med. Trop
موضوع المجلة:
MEDICINA TROPICAL
السنة:
2014
نوع:
Article