Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children
Clinics
; 69(4): 225-233, 4/2014. tab, graf
Article
ي En
| LILACS
| ID: lil-705784
المكتبة المسؤولة:
BR1.1
ABSTRACT
OBJECTIVE:
To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores.METHODS:
A randomized, double-blind, placebo-controlled trial was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for testing (a total of 120 children) were as follows (1) glutamine alone, n = 38; (2) glutamine plus vitamin A plus zinc, n = 37; and a placebo (zinc plus vitamin A vehicle) plus glycine (isonitrogenous to glutamine) control treatment, n = 38. Leptin, adiponectin, insulin-like growth factor (IGF-1), and plasma levels of cortisol were measured with immune-enzymatic assays; urinary lactulose/mannitol and serum amino acids were measured with high-performance liquid chromatography. ClinicalTrials.gov NCT00133406.RESULTS:
Glutamine treatment significantly improved weight-for-height z-scores compared to the placebo-glycine control treatment. Either glutamine alone or all nutrients combined prevented disruption of the intestinal barrier function, as measured by the percentage of lactulose urinary excretion and the lactulosemannitol absorption ratio. Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline. After glutamine treatment, leptin was correlated with weight-for-age (WAZ) and weight-for-height z-scores (WHZ) (p≤0.002) at a 4-month follow-up. In addition, glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children.CONCLUSION:
Taken together, these findings reveal the benefits of glutamine alone or in combination ...Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Vitamin A
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Vitamins
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Zinc
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Dietary Supplements
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Growth and Development
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Glutamine
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Intestinal Mucosa
نوع الدراسة:
Clinical_trials
المحددات:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
البلد/الأقليم حسب الموضوع:
America do sul
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Brasil
اللغة:
En
مجلة:
Clinics
موضوع المجلة:
MEDICINA
السنة:
2014
نوع:
Article
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Project document