The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
Mem. Inst. Oswaldo Cruz
; 109(5): 608-617, 19/08/2014. tab, graf
Article
ي En
| LILACS
| ID: lil-720427
المكتبة المسؤولة:
BR1.1
ABSTRACT
Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.
Key words
النص الكامل:
1
الفهرس:
LILACS
الموضوع الرئيسي:
Plasmodium vivax
/
Protozoan Proteins
/
Malaria, Vivax
/
Malaria Vaccines
/
Receptors, Cell Surface
/
Antigens, Protozoan
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
America do sul
/
Brasil
اللغة:
En
مجلة:
Mem. Inst. Oswaldo Cruz
موضوع المجلة:
MEDICINA TROPICAL
/
PARASITOLOGIA
السنة:
2014
نوع:
Article